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. 2022 Sep 5;23(17):10199. doi: 10.3390/ijms231710199

Figure 3.

Figure 3

Tubular deletion of IKKβ induces angiogenesis. (a) representative images of semi-thin sections from control and IKKβ∆Tub at baseline, 2 days and 14 days after I/R injury. Scale bar = 50 µm; (b) morphometric analysis of tubule–capillary contact length in %. Arithmetic means ± SEM of n = 3–6 per group; * p < 0.05, ** p < 0.01 using a Mann–Whitney–U test (if n < 4 Lord test). (c,d) Heatmaps of significantly altered mRNA of proteins known to affect angiogenesis at 2 days after I/R injury compared to baseline (c) and at 14 days after I/R injury compared to baseline (d). Filter criteria were DESeq p-values < 0.05; fold change > 1.5. All heatmaps show samples organized in columns and genes in rows, expression intensities are color-coded. The green stippled circle indicates mRNA of I/R groups used for relative expression in heatmaps by comparing only control with IKKβ∆Tub at 2 days (c) and 14 days (d) after I/R injury.