Figure 2.

Effects of indole-based benzenesulfonamide derivatives on the viability of cancer cells. (A) MDA-MB-231, (B) MCF-7, (C) SK-BR-3, (D) A549, and (E) Panc1 cells were treated with the test compounds (10 and 100 μM) for 48 h under CoCl₂-induced hypoxic condition. Control cells were treated with the media containing 0.2% dimethyl sulfoxide (DMSO) instead. Cell viability was determined by MTT assay as described in the Materials and Methods. The viability of vehicle (DMSO)-treated control cells was defined as 100%, and the viability of the cells treated with test compounds was expressed as a percentage of the control measured in the vehicle-treated cells in each cell line. Data are displayed as mean ± SEM from three independent experiments. * p < 0.05 vs. the vehicle-treated control cells. Con, control.