Table 1.
Plasma fatty acid percent composition of polar lipids and RBCs in female healthy control subjects and female hemodialysis patients.
| Fatty Acids | Plasma Polar Lipid Fatty Acids | RBC Fatty Acids | ||||
|---|---|---|---|---|---|---|
| Controls (n = 10) |
HDPs (n = 9) |
p-Values | Controls (n = 10) |
HDPs (n = 9) |
p-Values | |
| 14:0 | 1.23 ± 0.76 | 1.28 ± 0.63 | 0.9 | 0.17 ± 0.18 | 0.06 ± 0.13 | 0.14 |
| 15:0 | 0.09 ± 0.07 | ND | - | ND | ND | - |
| 16:0 | 24.15 ± 1.34 | 21.86 ± 1.44 | 0.0022 | 18.71 ± 1.17 | 18.37 ± 1.14 | 0.83 |
| t16:1n-7 | 0.15 ± 0.06 | 0.10 ± 0.09 | 0.2 | 0.03 ± 0.02 | 0.04 ± 0.03 | 0.53 |
| 16:1n-7 | 0.67 ± 0.36 | 0.40 ± 0.26 | 0.08 | 0.03 ± 0.05 | ND | - |
| 17:0 | 0.34 ± 0.05 | 0.33 ± 0.04 | 0.6 | 0.32 ± 0.26 | 0.06 ± 0.12 | 0.014 |
| 18:0 | 18.59 ± 1.45 | 20.47 ± 1.61 | 0.016 | 12.95 ± 1.27 | 12.91 ± 0.88 | 0.50 |
| 18:1n-9 | 10.82 ± 1.56 | 10.95 ± 2.23 | 0.9 | 16.78 ± 1.79 | 15.69 ± 1.85 | 0.46 |
| 18:1n-7 | 1.42 ± 0.23 | 1.66 ± 0.28 | 0.06 | 1.32 ± 0.17 | 1.47 ± 0.19 | 0.05 |
| 18:2n-6 | 18.16 ± 3.29 | 18.40 ± 2.28 | 0.9 | 11.25 ± 1.48 | 11.31 ± 1.73 | 0.93 |
| 18:3n-6 | 0.15 ± 0.11 | 0.05 ± 0.08 | 0.042 | 0.03 ± 0.06 | ND | - |
| 18:3n-3 | 0.34 ± 0.12 | 0.35 ± 0.10 | 0.8 | 0.04 ± 0.07 | ND | - |
| 20:0 | 0.16 ± 0.02 | 0.18 ± 0.04 | 0.2 | 0.04 ± 0.06 | 0.06 ± 0.13 | 0.71 |
| 20:1n-9 | 0.15 ± 0.06 | 0.19 ± 0.03 | 0.05 | 0.09 ± 0.11 | 0.18 ± 0.28 | 0.36 |
| 20:2n-6 | 0.34 ± 0.07 | 0.32 ± 0.06 | 0.5 | 0.26 ± 0.10 | 0.19 ± 0.19 | 0.34 |
| 20:3n-6 | 3.14 ± 0.82 | 2.15 ± 0.81 | 0.017 | 1.74 ± 0.28 | 1.27 ± 0.45 | 0.013 |
| 20:4n-6 | 11.47 ± 1.71 | 13.61 ± 1.87 | 0.019 | 15.98 ± 1.40 | 15.71 ± 3.49 | 0.83 |
| 20:5n-3 | 0.71 ± 0.28 | 0.38 ± 0.09 | 0.005 | 0.49 ± 0.13 | 0.11 ± 0.17 | 0.001 |
| 22:0 | 0.08 ± 0.06 | 0.04 ± 0.08 | 0.2 | 0.33 ± 0.12 | 0.41 ± 0.33 | 0.47 |
| 22:1n-9 | 0.18 ± 0.10 | 0.31 ± 0.14 | 0.032 | ND | 0.03 ± 0.08 | - |
| 22:4n-6 | 0.55 ± 0.15 | 0.52 ± 0.06 | 0.5 | 3.73 ± 0.71 | 4.04 ± 0.95 | 0.44 |
| 22:5n-6 | 0.43 ± 0.21 | 0.35 ± 0.10 | 0.3 | 0.84 ± 0.23 | 0.68 ± 0.30 | 0.22 |
| 22:5n-3 | 0.88 ± 0.11 | 0.71 ± 0.08 | 0.0013 | 1.98 ± 0.28 | 1.77 ± 0.47 | 0.25 |
| 22:6n-3 | 3.11 ± 1.57 | 2.68 ± 0.78 | 0.5 | 4.06 ± 1.40 | 3.63 ± 1.45 | 0.52 |
| 24:0 | 0.06 ± 0.05 | 0.03 ± 0.07 | 0.4 | 0.95 ± 0.15 | 0.93 ± 0.73 | 0.94 |
| 24:1n-9 | 0.09 ± 0.08 | 0.13 ± 0.08 | 0.3 | 0.91 ± 0.14 | 1.10 ± 0.90 | 0.54 |
| Total SFA | 44.71 ± 1.33 | 44.19 ± 2.13 | 0.5 | 36.11 ± 0.86 | 36.83 ± 3.87 | 0.54 |
| Total MUFA | 13.33 ± 1.77 | 13.65 ± 2.52 | 0.8 | 15.76 ± 1.30 | 16.32 ± 2.05 | 0.38 |
| Total PUFA | 39.29 ± 1.83 | 39.51 ± 1.87 | 0.8 | 40.39 ± 1.45 | 38.90 ± 7.83 | 0.50 |
| Total n-6 PUFA | 34.25 ± 1.88 | 35.40 ± 1.74 | 0.2 | 33.82 ± 1.93 | 33.19 ± 5.43 | 0.75 |
| Total n-3 PUFA | 5.04 ± 1.66 | 4.11 ± 0.91 | 0.15 | 6.56 ± 1.29 | 5.51 ± 1.93 | 0.18 |
| LC n-6 PUFA | 15.94 ± 2.13 | 16.94 ± 1.58 | 0.26 | 22.5 ± 0.93 | 21.88 ± 4.34 | 0.68 |
| LC n-3 PUFA | 4.71 ± 1.67 | 3.77 ± 0.85 | 0.15 | 6.52 ± 1.30 | 5.51 ± 1.93 | 0.19 |
| LC n-6/n-3 Ratio | 3.72 ± 1.29 | 4.65 ± 0.86 | 0.087 | 3.61 ± 0.88 | 4.79 ± 2.73 | 0.24 |
The fatty acid data were measured as fatty acid methyl esters as area % means ± SD of plasma polar lipid fatty acids and RBCs. Authentic external standards were used for peak identification of chromatogram data during integration. The sensitivity of the GC detector is at 10 ng/peak. HDPs = hemodialysis patients; LC n-6 = 20:2n-6 + 20:3n-6 + 20:4n-6 + 22:4n-6 + 22:5n-6; LC n-3 = 20:5n-3 + 22:5n-3 + 22:6n-3. ND = not detected.