Table 2.
Compound | Parent Fatty Acid |
Units | Control | HDP | VIP | p-Value |
---|---|---|---|---|---|---|
Monoacylglycerols | ||||||
2-OG | OA | nM | 38.3 ± 13 | 65.8 ± 38 | 1.3 | 0.1 |
1-LG | LA | nM | 6.25 ± 6 | 10.6 ± 5.9 | 1.4 | 0.033 |
2-LG | ““ | nM | 30.5 ± 15 | 67 ± 42 | 1.6 | 0.026 |
N-Acylethanolamides | ||||||
O-EA | OA | nM | 14.1 ± 5.1 | 24.5 ± 9.7 | 1.8 | 0.0086 |
L-EA | LA | nM | 5.8 ± 1.5 | 10.4 ± 4.1 | 1.9 | 0.0017 b |
αL-EA | αLEA | nM | 0.082 ± 0.03 | 0.154 ± 0.091 | 1.5 | 0.024 |
A-EA | AA | nM | 1.59 ± 0.3 | 1.88 ± 0.71 | 1.0 | 0.5 |
D-EA | AdA | nM | 0.734 ± 0.19 | 1.06 ± 0.32 | 1.6 | 0.023 |
Prostanoids | ||||||
6-ketoPGF1a | AA | nM | 0.177 ± 0.078 | 0.377 ± 0.34 | 1.1 | 0.1 |
PGD2 | ““ | 0.0938 ± 0.046 | 0.196 ± 0.2 | 1.1 | 0.2 | |
Triols | ||||||
9,12,13-TriHOME | LA | nM | 2.51 ± 1.3 | 1.59 ± 0.6 | 1.2 | 0.063 |
9,10-13-TriHOME | ““ | nM | 3.9 ± 1.9 | 2.35 ± 0.89 | 1.4 | 0.019 |
Alcohols | ||||||
15-HETE | AA | nM | 1.66 ± 0.68 | 1.19 ± 0.51 | 1.1 | 0.1 |
12-HETE | ““ | nM | 15.6 ± 10 | 9.68 ± 8.4 | 1.0 | 0.1 |
11-HETE | ““ | nM | 0.318 ± 0.13 | 0.221 ± 0.12 | 1.0 | 0.1 |
9-HETE | ““ | nM | 0.46 ± 0.15 | 0.316 ± 0.17 | 1.2 | 0.070 |
12-HEPE | EPA | nM | 1.92 ± 1.4 | 0.76 ± 0.67 | 1.3 | 0.037 |
5-HEPE | ““ | nM | 0.295 ± 0.16 | 0.147 ± 0.077 | 1.4 | 0.026 |
Hydroperoxides | ||||||
12-HpETE | AA | Fold-C | 1.0 ± 1.3 | 0.35 ± 0.35 | 1.1 | 0.087 |
5-HpETE | AA | Fold C | 1.0 ± 1.0 | 0.42 ± 0.33 | 1.1 | 0.1 |
Epoxides | ||||||
14(15)-EpETrE | AA | nM | 0.437 ± 0.28 | 0.203 ± 0.11 | 1.5 | 0.014 |
11(12)-EpETrE | ““ | nM | 0.551 ± 0.32 | 0.309 ± 0.17 | 1.3 | 0.06 |
8(9)-EpETrE | ““ | nM | 0.195 ± 0.13 | 0.0822 ± 0.068 | 1.0 | 0.1 |
17(18)-EpETE | EPA | nM | 0.124 ± 0.11 | 0.0478 ± 0.019 | 1.0 | 0.1 |
19(20)-EpDPE | DHA | nM | 0.484 ± 0.38 | 0.212 ± 0.09 | 1.4 | 0.019 |
Diols | ||||||
11,12-DiHETrE | AA | nM | 0.372 ± 0.084 | 0.287 ± 0.089 | 1.3 | 0.031 |
17,18-DiHETE | EPA | nM | 2.5 ± 1.1 | 1.79 ± 0.66 | 1.0 | 0.1 |
14,15-DiHETE | ““ | nM | 0.378 ± 0.16 | 0.247 ± 0.15 | 1.2 | 0.057 |
a—all values are mean ± SD. Variable importance in projection (VIP) scores are reported from partial least squares-discriminant models of all measured metabolites. The p-values are 2-tailed t-tests comparing group means. b—difference in L-EA between groups that survived false discover rate correction at q = 0.2. Abbreviations: AA = arachidonic acid; AdA = adrenic acid; αLEA = alpha-linoleic acid; DHA = docosahexaenoic acid; EPA = eicosapentaenoic acid; Fold-C = fold-control, i.e., control ÷ HDP; HDP = hemodialysis patient; LA = linoleic acid; OA = oleic acid.