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. 2022 Aug 29;23(17):9781. doi: 10.3390/ijms23179781

Table 2.

Plasma endocannabinoid and oxylipin subset levels in healthy controls and hemodialysis patients a,b.

Compound Parent
Fatty Acid
Units Control HDP VIP p-Value
Monoacylglycerols
2-OG OA nM 38.3 ± 13 65.8 ± 38 1.3 0.1
1-LG LA nM 6.25 ± 6 10.6 ± 5.9 1.4 0.033
2-LG ““ nM 30.5 ± 15 67 ± 42 1.6 0.026
N-Acylethanolamides
O-EA OA nM 14.1 ± 5.1 24.5 ± 9.7 1.8 0.0086
L-EA LA nM 5.8 ± 1.5 10.4 ± 4.1 1.9 0.0017 b
αL-EA αLEA nM 0.082 ± 0.03 0.154 ± 0.091 1.5 0.024
A-EA AA nM 1.59 ± 0.3 1.88 ± 0.71 1.0 0.5
D-EA AdA nM 0.734 ± 0.19 1.06 ± 0.32 1.6 0.023
Prostanoids
6-ketoPGF1a AA nM 0.177 ± 0.078 0.377 ± 0.34 1.1 0.1
PGD2 ““ 0.0938 ± 0.046 0.196 ± 0.2 1.1 0.2
Triols
9,12,13-TriHOME LA nM 2.51 ± 1.3 1.59 ± 0.6 1.2 0.063
9,10-13-TriHOME ““ nM 3.9 ± 1.9 2.35 ± 0.89 1.4 0.019
Alcohols
15-HETE AA nM 1.66 ± 0.68 1.19 ± 0.51 1.1 0.1
12-HETE ““ nM 15.6 ± 10 9.68 ± 8.4 1.0 0.1
11-HETE ““ nM 0.318 ± 0.13 0.221 ± 0.12 1.0 0.1
9-HETE ““ nM 0.46 ± 0.15 0.316 ± 0.17 1.2 0.070
12-HEPE EPA nM 1.92 ± 1.4 0.76 ± 0.67 1.3 0.037
5-HEPE ““ nM 0.295 ± 0.16 0.147 ± 0.077 1.4 0.026
Hydroperoxides
12-HpETE AA Fold-C 1.0 ± 1.3 0.35 ± 0.35 1.1 0.087
5-HpETE AA Fold C 1.0 ± 1.0 0.42 ± 0.33 1.1 0.1
Epoxides
14(15)-EpETrE AA nM 0.437 ± 0.28 0.203 ± 0.11 1.5 0.014
11(12)-EpETrE ““ nM 0.551 ± 0.32 0.309 ± 0.17 1.3 0.06
8(9)-EpETrE ““ nM 0.195 ± 0.13 0.0822 ± 0.068 1.0 0.1
17(18)-EpETE EPA nM 0.124 ± 0.11 0.0478 ± 0.019 1.0 0.1
19(20)-EpDPE DHA nM 0.484 ± 0.38 0.212 ± 0.09 1.4 0.019
Diols
11,12-DiHETrE AA nM 0.372 ± 0.084 0.287 ± 0.089 1.3 0.031
17,18-DiHETE EPA nM 2.5 ± 1.1 1.79 ± 0.66 1.0 0.1
14,15-DiHETE ““ nM 0.378 ± 0.16 0.247 ± 0.15 1.2 0.057

a—all values are mean ± SD. Variable importance in projection (VIP) scores are reported from partial least squares-discriminant models of all measured metabolites. The p-values are 2-tailed t-tests comparing group means. b—difference in L-EA between groups that survived false discover rate correction at q = 0.2. Abbreviations: AA = arachidonic acid; AdA = adrenic acid; αLEA = alpha-linoleic acid; DHA = docosahexaenoic acid; EPA = eicosapentaenoic acid; Fold-C = fold-control, i.e., control ÷ HDP; HDP = hemodialysis patient; LA = linoleic acid; OA = oleic acid.