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. 2022 Aug 30;23(17):9833. doi: 10.3390/ijms23179833

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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LAIR-1 mediates suppression of CIA. Two groups (n = 10 per group) of DR1/LAIR-1^+/+ mice and two groups of littermate DR1/LAIR-1⁻^/− mice were immunized with type II collagen/CFA. Then, each mouse was administered intraperitoneally a dose of either 100µg CI or PBS weekly for four weeks beginning one week after immunization. Each mouse was scored three times weekly beginning 2 weeks post immunization. The severity of the arthritis was statistically significant comparing CI treatment with PBS in LAIR-1^+/+ mice beginning on day 44 (p ≤ 0.05) post immunization and continuing until the end of the experiment on day 56. (p ≤ 0.001).