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. 2022 Sep 1;23(17):9993. doi: 10.3390/ijms23179993

Figure 1.

Figure 1

Effect of 3 week tenapanor treatment on body weight, stool water content, and stool pH in cftr+/+ and cftr−/− mice. (a) Schematic description of experimental protocol. (b) Initial body weight (grams) of the male and female mice that did or did not develop obstructions. (c) The body weight remained stable during the 3 week gavage period in the cftr+/+ mice and (d) slightly decreased in the cftr−/− mice, irrespective of treatment with tenapanor or vehicle. (e) A significantly higher stool water content was seen in the tenapanor-treated cftr+/+ and (f) cftr−/− mice in comparison to the vehicle-treated groups. (g) Increased stool alkalinity 3 h post-gavage with tenapanor. Each dot/triangle represents one mouse. cftr+/+: n = 10 in both tenapanor-treated and vehicle-treated groups; cftr−/−: n = 12 in the tenapanor-treated and n = 13 in the vehicle-treated group. Data are represented as means ± SEM. # is used to represent the statistical analysis performed between the two different genotypes and * is used to represent the statistical analysis performed between the vehicle and tenapanor groups and between the same genotype, pre- and post-tenapanor gavage. # and *, p < 0.05.