Figure 2.

Faster GI transit time (GTT) in tenapanor-treated mice. (a,c) GTT was measured once per week, and it decreased in both cftr^+/+ and cftr^−/− mice from week 1 to week 3 and was decreased after gavage with tenapanor compared to vehicle. (b,d) The longitudinal assessment of the stool water content during the 5 h post-gavage showed a significant increase with tenapanor compared to vehicle treatment. 0 h indicates stool samples collected pre-gavage. Each dot/triangle in the GI transit measurement represents one mouse, with the same mouse then being simultaneously assessed for stool water content. Data are represented as means ± SEM. * p < 0.05.