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Significantly lower incidence of obstructions in tenapanor-treated cftr−/− mice. (a) Treatment with tenapanor resulted in a significant reduction in the incidence of intestinal obstructions in cftr−/− mice compared to the vehicle-treated cftr−/− mice. (b) A representative image of the obstruction between the ileum and proximal colon is shown. All mice but one were suspected to have suffered an obstruction while alive and were sacrificed prior to death. * p < 0.05.
