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. 2022 Sep 1;23(17):9993. doi: 10.3390/ijms23179993

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Decrease in mucus accumulation in tenapanor-treated cftr^−/− mice. (a) Representative images of Muc2 immunohistochemistry (major component of the secreted colonic mucin) of jejunum, ileum, proximal colon, and mid-distal colon in cftr^+/+ and cftr^−/− mice treated with either vehicle or tenapanor (n = 5/genotype/group/intestinal segment). (b) Fluorescent intensity (I.D) ratio of Muc2 in relation to Dapi immunofluorescence (c) localized to the goblet cell thecae (intracellular mucus pool) and (d) localized to the luminal compartment (secreted mucus). (e) mRNA expression of Muc1 in these intestinal segments. Each dot/triangle represents one mouse. Veh—vehicle, Ten—tenapanor, UO—unobstructed, O—obstructed, I.D—Integrated density. Data are represented as means ± SEM. # is used to represent the statistical analysis performed between the two different genotypes and * is used to represent the statistical analysis performed between the vehicle and tenapanor groups or between unobstructed and obstructed vehicle groups. # and *, p < 0.05.