Figure 8.

Inflammation in obstructed cftr^−/− mice treated with vehicle. The mRNA expression of pro-inflammatory cytokines (a) Tnfα, (b) Mcp1, and (c) Il1β were not significantly different between genotypes or between the tenapanor vs. vehicle-treated mice without obstruction but showed a dramatic increase in the ileum and proximal colon of obstructed cftr^−/− mice. Each dot/triangle represents one mouse. Veh—vehicle, Ten—tenapanor, UO—unobstructed, O—obstructed. Data are represented as means ± SEM. # is used to represent the statistical analysis performed between the two different genotypes and * is used to represent the statistical analysis performed between the vehicle and tenapanor groups or between unobstructed and obstructed vehicle groups. # and *, p < 0.05.