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Exercise upregulates the AdipoR1 levels in the brains of AD mice. (A) Serum APN protein levels were measured by ELISA (n = 6). (B) Brain tissue APN protein levels were measured by ELISA (n = 4). (C) Relative protein levels of AdipoR1 in brain tissue (n = 6). (D) The relative expression of AdipoR1 mRNA in brain tissue was measured by RT-PCR (n = 5). Data are presented as means ± SDs. # p < 0.05, ## p < 0.01 vs. WT + SED mice, * p < 0.05, and *** p < 0.001 vs. AP + SED mice.
