Table 2.
The distribution of diagnoses in control group.
| Diagnostic Category | Causes |
|---|---|
|
Immune-Mediated Inflammatory Diseases 35% (n = 70) |
Idiopathic pericarditis (n = 19) |
| Rheumatoid arthritis (n = 13) | |
| Miscellaneous systemic disorders (n = 10): TAFRO syndrome, inflammatory bowel disease, Sjögren’s syndrome, relapsing polychondritis, IgG4-related disease, autoimmune myositis | |
| Systemic lupus erythematosus (n = 9) | |
| Giant cell arteritis or polymyalgia rheumatica (n = 6) | |
| Spondyloarthropathies (n = 5) | |
| Vasculitis (n = 5): Polyarteritis nodosa, Urticarial vasculitis, Cryoglobulinemic vasculitis, Anti-neutrophil cytoplasmic autoantibody-associated vasculitis | |
| Autoinflammatory syndromes (n = 3): NLRP3 mutation, NLRC4 mutation, ROSAH syndrome | |
|
Infectious Diseases 25 % (n = 51) |
Pyogenic bacteria (n = 22): Enterobacteriaceae, Staphylococcus, Streptococcus, Anaerobic |
| Viral infection (n = 21): Human herpesvirus (EBV, CMV), Influenza, Parvovirus B19, human immunodeficiency viruses (HIV) | |
| Intracellular bacteria (n = 7): Tuberculosis, Coxiella burnetii, Tropheryma whipplei, Legionella | |
| Parasitic disease (n = 1): Blastocystis hominis | |
|
Hematologic Malignancies 12% (n = 24) |
Lymphoid malignancies (n = 15): Hodgkin lymphoma, B cell non-Hodgkin lymphoma, T cell non-Hodgkin lymphoma, multiple myeloma |
| Myeloid malignancies (n = 9): acute leukemia, myelodysplastic syndrome, VEXAS syndrome, mastocytosis | |
|
Solid Cancers 5% (n = 11) |
Metastatic cancer (n = 7) |
| Localized cancer (n = 4) | |
|
Acute Hepatitis 5% (n = 11) |
Drug induced hepatitis (n = 5) |
| Autoimmune hepatitis (n = 3) | |
| Viral hepatitis (n = 3) | |
|
Other 18% (n = 36) |
Crystal arthropathies (n = 5) |
| Urticaria (n = 8) | |
| Various (n = 23): DRESS syndrome, Osteoarthritis, Dressler syndrome, Thrombotic microangiopathy, Venous Thromboembolic Disease, Fever of unknown origin, Fibromyalgia, Focal and segmental glomerulosclerosis, Myocardial infarction, subacute granulomatous thyroiditis, Alcohol use disorder |
Abbreviations: NLRP3, NOD-like receptor family, pyrin domain containing protein 3; NLRC4, NOD-like receptor family CARD domain containing protein 4; EBV, Epstein–Barr virus; CMV, cytomegalovirus; VEXAS syndrome, Vacuoles E1-enzyme X-linked Autoinflammatory and Somatic syndrome; ROSAH syndrome, Retinal dystrophy Optic nerve edema Splenomegaly Anhidrosis and migraine Headache syndrome; TAFRO syndrome, Thrombocytopenia Anasarca reticulin Fibrosis Renal insufficiency and Organomegaly syndrome (idiopathic multicentric Castleman disease subtype); Abbreviations need to be redefined in the first time they are used in both figures and tables. Drug reaction with eosinophilia and systemic symptoms.