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. 2022 Aug 30;23(17):9863. doi: 10.3390/ijms23179863

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A–E) Effects of α-boswellic acid on the TNF-α/IFN-γ-induced proinflammatory cytokines and chemokine mRNA expressions in HaCaT cells. (F–H) Effects of α-boswellic acid on involucrin, filaggrin, and loricrin mRNA expressions in TNF-α/IFN-γ-induced HaCaT cells. HaCaT cells were pretreated with different concentrations of α-boswellic acid—1, 3, and 10 μM—for 20 min, and then the cells were treated with TNF-α/IFN-γ for 6 h. Total RNA was isolated and the mRNA expression level of IL-1β, IL-6, IL-8, MDC, TARC, involucrin, filaggrin, and loricrin were determined using qPCR. Values represent the mean ± SEM from three or four independent experiments. ## p < 0.01 compared with the no-treatment condition; * p < 0.05 and ** p < 0.01 compared with the only TNF-α/IFN-γ treatment condition.

(A–E) Effects of α-boswellic acid on the TNF-α/IFN-γ-induced proinflammatory cytokines and chemokine mRNA expressions in HaCaT cells. (F–H) Effects of α-boswellic acid on involucrin, filaggrin, and loricrin mRNA expressions in TNF-α/IFN-γ-induced HaCaT cells. HaCaT cells were pretreated with different concentrations of α-boswellic acid—1, 3, and 10 μM—for 20 min, and then the cells were treated with TNF-α/IFN-γ for 6 h. Total RNA was isolated and the mRNA expression level of IL-1β, IL-6, IL-8, MDC, TARC, involucrin, filaggrin, and loricrin were determined using qPCR. Values represent the mean ± SEM from three or four independent experiments. ## p < 0.01 compared with the no-treatment condition; * p < 0.05 and ** p < 0.01 compared with the only TNF-α/IFN-γ treatment condition.