Table 3.
Clinical outcomes between the DM and non-DM groups at 2 years.
| Outcomes | NSTEMI (n = 5093) | Log-Rank | Unadjusted | Multivariable-Adjusted a | |||
|---|---|---|---|---|---|---|---|
| DM (n = 2399) |
Non-DM (n = 2694) |
HR (95% CI) | p | HR (95% CI) | p | ||
| MACE | 219 (10.0) | 175 (7.3) | 0.001 | 1.391 (1.140–1.696) | 0.001 | 1.326 (1.080–1.629) | 0.007 |
| All-cause death | 98 (4.5) | 58 (2.5) | <0.001 | 1.873 (1.354–2.592) | <0.001 | 1.701 (1.215–2.382) | 0.002 |
| Cardiac death | 54 (2.5) | 40 (1.7) | 0.051 | 1.498 (0.995–2.255) | 0.053 | 1.325 (0.866–2.027) | 0.195 |
| Non-cardiac death | 44 (2.0) | 18 (0.8) | <0.001 | 2.706 (1.564–4.683) | <0.001 | 2.549 (1.450–4.480) | 0.001 |
| Recurrent MI | 61 (2.9) | 46 (1.9) | 0.048 | 1.469 (1.002–2.154) | 0.049 | 1.469 (0.990–2.180) | 0.056 |
| Any repeat revascularization | 95 (4.5) | 84 (3.6) | 0.124 | 1.259 (0.938–1.688) | 0.125 | 1.223 (0.904–1.654) | 0.191 |
| ST (definite or probable) | 20 (0.8) | 9 (0.3) | 0.018 | 2.501 (1.139–5.492) | 0.022 | 2.272 (1.010–5.023) | 0.048 |
| Outcomes | STEMI (n = 6705) | Log-rank | Unadjusted | Multivariable-Adjusted a | |||
|
DM
(n = 2693) |
Non-DM
(n = 4012) |
HR (95% CI) | p | HR (95% CI) | p | ||
| MACE | 211 (8.4) | 208 (5.6) | <0.001 | 1.507 (1.244–1.825) | <0.001 | 1.481 (1.218–1.801) | <0.001 |
| All-cause death | 78 (3.1) | 59 (1.6) | <0.001 | 1.961 (1.399–2.751) | <0.001 | 1.869 (1.322–2.643) | <0.001 |
| Cardiac death | 57 (2.2) | 35 (0.9) | <0.001 | 2.419 (1.588–3.684) | <0.001 | 2.248 (1.462–3.458) | <0.001 |
| Non-cardiac death | 21 (0.9) | 24 (0.7) | 0.385 | 1.296 (0.721–2.327) | 0.386 | 1.307 (0.716–2.384) | 0.383 |
| Recurrent MI | 59 (2.4) | 57 (1.5) | 0.020 | 1.535 (1.067–2.209) | 0.021 | 1.537 (1.060–2.228) | 0.023 |
| Any repeat revascularization | 99 (4.1) | 108 (3.0) | 0.027 | 1.360 (1.035–1.786) | 0.027 | 1.374 (1.041–1.816) | 0.024 |
| ST (definite or probable) | 25 (0.9) | 27 (0.7) | 0.244 | 1.380 (0.801–2.377) | 0.246 | 1.381 (0.792–2.224) | 0.315 |
| Outcomes | Overall (n = 11,798) | Log-rank | Unadjusted | Multivariable-Adjusted a | |||
|
DM
(n = 5092) |
Non-DM
(n = 6706) |
HR (95% CI) | p | HR (95% CI) | p | ||
| MACE | 430 (9.1) | 383 (6.2) | <0.001 | 1.473 (1.283–1.690) | <0.001 | 1.434 (1.245–1.652) | <0.001 |
| All-cause death | 176 (3.7) | 117 (1.9) | <0.001 | 1.969 (1.558–2.488) | <0.001 | 1.866 (1.467–2.374) | <0.001 |
| Cardiac death | 111 (2.3) | 75 (1.2) | <0.001 | 1.939 (1.447–2.599) | <0.001 | 1.818 (1.345–2.457) | <0.001 |
| Non-cardiac death | 65 (1.4) | 42 (0.7) | <0.001 | 2.022 (1.372–2.981) | <0.001 | 1.957 (1.313–2.916) | 0.001 |
| Recurrent MI | 120 (2.7) | 103 (1.7) | 0.002 | 1.524 (1.171–1.983) | 0.002 | 1.527 (1.166–2.000) | 0.002 |
| Any repeat revascularization | 194 (4.0) | 192 (3.4) | 0.006 | 1.324 (1.085–1.617) | 0.006 | 1.314 (1.071–1.611) | 0.009 |
| ST (definite or probable) | 45 (0.9) | 36 (0.5) | 0.024 | 1.648 (1.063–2.554) | 0.026 | 1.521 (1.027–2.351) | 0.037 |
NSTEMI, non-ST-segment elevation myocardial infarction; STEMI, ST-segment elevation myocardial infarction; DM, diabetes mellitus; HR, hazard ratio; CI, confidence interval; MACE, major adverse cardiac events; ST, stent thrombosis; LVEF, left ventricular ejection fraction; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; CPR, cardiopulmonary resuscitation; PCI, percutaneous coronary intervention; CABG, coronary artery bypass graft; HF, heart failure; CVA, cerebrovascular accidents; CK-MB, creatine kinase myocardial band; NT-ProBNP, N-terminal pro-brain natriuretic peptide; eGFR, estimated glomerular filtration rate; LDL, low-density lipoprotein; ACEI, angiotensin converting enzyme inhibitor. a Adjusted by male sex, age, LVEF, BMI, SBP, DBP, cardiogenic shock, Killip class I/II, CPR on admission, hypertension, previous histories (MI, PCI, CABG, HF, and CVA), current smoker, peak CK-MB, peak troponin-I, NT-ProBNP, serum creatinine, eGFR, total cholesterol, LDL cholesterol, and year of index MI (Supplementary Tables S3 and S6).