Table 2.
dcSSc (N = 73) |
lcSSc (N = 299) |
P | ILD (N = 146) |
No ILD (N = 225) |
P * | PH (N = 12) |
No PH (N = 360) |
P | Gastrointestinal involvement (N = 311) |
No Gastrointestinal Involvement (N = 61) |
P | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
White blood cells G/L | 7.3 (6.1; 8.9) | 6.4 (5.3; 7.8) | 0.001 | 7.1 (5.8; 8.8) | 6.3 (5.1; 7.6) | 0.001 | 7.0 (5.7; 9.7) | 6.6 (5.5; 7.9) | 0.56 | 6.6 (5.5; 7.9) | 6.5 (5.1; 8.1) | 0.58 |
Monocytes G/L | 0.6 (0.5; 0.8) | 0.6 (0.4; 0.7) | <0.001 | 0.6 (0.5; 0.8) | 0.5 (0.4; 0.6) | <0.001 | 0.6 (0.4; 0.7) | 0.6 (0.4; 0.7) | 0.82 | 0.6 (0.5; 0.7) | 0.6 (0.4; 0.7) | 0.29 |
Neutrophils G/L | 4.8 (3.5; 5.8) | 3.8 (3.0; 4.8) | <0.001 | 4.3 (3.5; 5.6) | 3.7 (2.9; 4.6) | <0.001 | 4.5 (3.7; 6.4) | 4.0 (3.1; 5.0) | 0.33 | 4.0 (3.1; 5.0) | 3.9 (2.9; 5.1) | 0.50 |
Eosinophils G/L | 0.1 (0.1; 0.2) | 0.2 (0.1; 0.3) | 0.010 | 0.2 (0.1; 0.2) | 0.2 (0.1; 0.3) | 0.58 | 0.1 (0.1; 0.3) | 0.2 (0.1; 0.2) | 0.76 | 0.2 (0.1; 0.3) | 0.1 (0.1; 0.2) | 0.079 |
Lymphocytes G/L | 1.6 (1.3; 2.3) | 1.7 (1.2; 2.1) | 0.75 | 1.6 (1.2; 2.3) | 1.7 (1.2; 2.1) | 0.34 | 1.7 (0.9; 2.2) | 1.7 (1.2; 2.1) | 0.67 | 1.7 (1.2; 2.1) | 1.6 (1.3; 2.1) | 0.73 |
Basophils G/L | 0.0 (0.0; 0.1) | 0.0 (0.0; 0.1) | 0.47 | 0.0 (0.0; 0.1) | 0.0 (0.0; 0.1) | 0.26 | 0.0 (0.0; 0.1) | 0.0 (0.0; 0.1) | 0.47 | 0.0 (0.0; 0.1) | 0.0 (0.0; 0.1) | 0.62 |
Hemoglobin g/dL | 13.1 (12.5; 14.0) | 13.3 (12.5; 14.1) | 0.69 | 13.1 (12.4; 14.0) | 13.4 (12.5; 14.1) | 0.47 | 12.1 (10.6; 13.2) | 13.3 (12.5; 14.1) | 0.016 | 13.3 (12.5; 14.0) | 13.3 (12.8; 14.2) | 0.24 |
Platelets G/L | 264.0 (226.0; 311.0) | 255.0 (215.0; 297.0) | 0.33 | 265.0 (228.0; 307.0) | 250.5 (210.0; 293.0) | 0.14 | 236.0 (204.0; 276.0) | 256.0 (216.0; 303.0) | 0.24 | 257.0 (222.0; 305.0) | 239.0 (200.0; 292.0) | 0.14 |
CRP mg/L | 3.0 (3.0; 6.0) | 3.0 (3.0; 4.0) | 0.064 | 3.0 (3.0; 6.0) | 3.0 (3.0; 4.0) | 0.003 | 3.0 (3.0; 5.0) | 3.0 (3.0; 4.0) | 0.85 | 3.0 (3.0; 5.0) | 3.0 (3.0; 3.0) | 0.24 |
ESR mm/h | 9.0 (2.0; 19.0) | 11.0 (6.0; 21.0) | 0.34 | 11.0 (6.0; 22.0) | 10.0 (6.0; 18.0) | 0.62 | 11.0 (5.0; 32.0) | 10.5 (6.0; 19.0) | 0.52 | 11.0 (6.0; 19.0) | 10.0 (6.0; 23.0) | 0.79 |
NT pro BNP ng/L | 105.5 (45.0; 309.0) | 89.0 (55.0; 177.0) | 0.31 | 98.0 (57.0; 281.0) | 88.0 (53.0; 168.0) | 0.26 | 608.5 (291.0; 1449) | 89.5 (53.0; 185.5) | <0.001 | 93.0 (57.0; 206.0) | 76.0 (45.0; 161.0) | 0.28 |
Ferritin ng/mL | 76.0 (32.0; 160.0) | 70.0 (33.0; 135.0) | 0.51 | 78.0 (32.0; 143.0) | 68.0 (33.0; 137.0) | 0.67 | 32.5 (14.0; 56.0) | 73.5 (34.0; 142.0) | 0.046 | 64.0 (28.0; 132.0) | 101.0 (73.0; 187.0) | <0.001 |
Uric acid mg/L | 48.0 (35.5; 57.0) | 48.0 (39.0; 57.0) | 0.42 | 48.0 (36.0; 57.0) | 48.0 (40.0; 57.0) | 0.50 | 59.0 (52.5; 72.5) | 48.0 (38.0; 56.0) | 0.012 | 48.0 (38.0; 56.0) | 48.0 (41.0; 61.0) | 0.17 |
AST UI/L | 20.0 (17.0; 23.0) | 22.0 (19.0; 26.0) | 0.007 | 21.0 (18.0; 25.0) | 22.0 (18.0; 26.0) | 0.52 | 20.0 (18.0; 22.0) | 22.0 (18.0; 26.0) | 0.23 | 21.0 (18.0; 26.0) | 22.0 (18.0; 25.0) | 0.60 |
ALT UI/L | 16.0 (11.0; 20.0) | 16.0 (13.0; 22.0) | 0.070 | 16.0 (12.0; 22.0) | 15.5 (13.0; 21.0) | 0.97 | 12.5 (9.0; 15.0) | 16.0 (12.0; 21.5) | 0.035 | 16.0 (12.0; 21.0) | 17.0 (13.5; 22.0) | 0.53 |
ALP UI/L | 60.0 (51.0; 76.0) | 65.0 (53.0; 86.0) | 0.11 | 62.0 (52.0; 80.0) | 66.0 (52.0; 85.0) | 0.20 | 73.0 (56.0; 110.0) | 64.0 (52.0; 83.0) | 0.16 | 65.0 (52.0; 85.0) | 63.0 (50.0; 81.5) | 0.40 |
GGT UI/L | 20.0 (12.0; 31.0) | 21.0 (14.0; 39.0) | 0.25 | 22.0 (15.0; 40.0) | 20.0 (14.0; 36.0) | 0.85 | 18.0 (14.0; 65.0) | 21.0 (14.0; 37.0) | 0.74 | 21.0 (14.0; 38.0) | 20.0 (13.0; 39.0) | 0.51 |
Total bilirubin mg/L | 4.0 (3.0; 5.0) | 4.0 (3.0; 5.0) | 0.58 | 4.0 (3.0; 5.0) | 4.0 (3.0; 5.0) | 0.58 | 3.5 (3.0; 6.0) | 4.0 (3.0; 5.0) | 0.97 | 4.0 (3.0; 5.0) | 4.0 (3.0; 6.0) | 0.025 |
Serum sodium mmol/L |
140.0 (139.0; 142.0) | 140.0 (139.0; 142.0) | 0.51 | 140.0 (139.0; 141.0) | 140.5 (139.0; 142.0) | 0.11 | 139.5 (137.0; 141.0) | 140.0 (139.0; 142.0) | 0.33 | 140.0 (139.0; 142.0) | 140.0 (138.0; 141.5) | 0.17 |
Serum potassium mmol/L |
4.0 (3.9; 4.4) | 4.2 (4.0; 4.4) | 0.039 | 4.1 (3.9; 4.4) | 4.2 (4.0; 4.4) | 0.57 | 4.2 (3.8; 4.4) | 4.2 (4.0; 4.4) | 0.96 | 4.2 (4.0; 4.4) | 4.1 (4.0; 4.4) | 0.27 |
Urea g/L | 0.3 (0.3; 0.4) | 0.3 (0.3; 0.4) | 0.88 | 0.3 (0.3; 0.4) | 0.3 (0.3; 0.4) | 0.75 | 0.4 (0.4; 0.5) | 0.3 (0.3; 0.4) | 0.003 | 0.3 (0.3; 0.4) | 0.3 (0.3; 0.4) | 0.33 |
Creatinin mg/L | 8.0 (7.0; 9.0) | 8.0 (7.0; 9.0) | 0.70 | 8.0 (7.0; 9.0) | 7.0 (7.0; 9.0) | 0.21 | 9.0 (7.5; 10.5) | 8.0 (7.0; 9.0) | 0.039 | 8.0 (7.0; 9.0) | 8.0 (7.0; 9.0) | 0.90 |
A1globulins g/L | 3.0 (2.7; 3.4) | 2.9 (2.6; 3.2) | 0.023 | 2.9 (2.7; 3.3) | 2.8 (2.5; 3.2) | 0.24 | 3.2 (2.8; 3.5) | 2.9 (2.6; 3.2) | 0.11 | 2.9 (2.6; 3.2) | 2.9 (2.6; 3.2) | 1.00 |
A2globulins g/L | 7.8 (6.8; 8.4) | 7.5 (6.9; 8.2) | 0.31 | 7.7 (6.9; 8.4) | 7.5 (6.8; 8.1) | 0.36 | 7.6 (7.4; 9.0) | 7.6 (6.8; 8.2) | 0.43 | 7.6 (6.9; 8.3) | 7.4 (6.5; 8.0) | 0.12 |
Betaglobulins g/L | 7.9 (7.3; 8.5) | 7.7 (7.1; 8.4) | 0.48 | 7.7 (7.2; 8.4) | 7.7 (7.1; 8.4) | 0.97 | 7.9 (7.5; 9.1) | 7.7 (7.1; 8.4) | 0.52 | 7.7 (7.1; 8.4) | 7.7 (7.2; 8.4) | 0.60 |
Gammaglobulins g/L | 10.3 (7.8; 13.5) | 9.8 (8.4; 11.6) | 0.33 | 10.1 (8.0; 12.4) | 9.8 (8.5; 11.9) | 0.93 | 10.9 (10.5; 12.8) | 9.9 (8.2; 12.0) | 0.059 | 9.9 (8.2; 12.0) | 10.1 (9.0; 12.8) | 0.21 |
Albumin g/L | 40.3 (38.0; 44.0) | 41.0 (39.0; 43.0) | 0.27 | 40.3 (38.0; 43.0) | 41.0 (39.1; 43.0) | 0.21 | 39.4 (37.2; 41.0) | 41.0 (38.8; 43.0) | 0.064 | 41.0 (38.5; 43.0) | 41.1 (39.7; 44.0) | 0.15 |
Values are presented as median (interquartile range [IQR]). dcSSc: diffuse cutaneous systemic sclerosis; lcSSc: limited cutaneous systemic sclerosis; ILD: interstitial lung disease; PH: pulmonary hypertension; SSc: systemic sclerosis; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; ALP: alkaline phosphatase; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: gammaglutamyltranspeptidase; NTproBNP: N-terminal pro-brain natriuretic peptide; G/L: Giga/Liter; A1 globulins: alpha 1 globulins; A2 globulins: Alpha 2 globulins; No: Non ILD, non PH, and non-gastrointestinal tract involvement; P: p value < 0.05 (significant results appear in bold in the table). * p values are adjusted for type of SSc.