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. 2022 Aug 30;11(17):5087. doi: 10.3390/jcm11175087

Table 2.

Routine laboratory parameters as biomarkers of severity in systemic sclerosis.

dcSSc
(N = 73)
lcSSc
(N = 299)
P ILD
(N = 146)
No ILD
(N = 225)
P * PH
(N = 12)
No PH
(N = 360)
P Gastrointestinal involvement
(N = 311)
No Gastrointestinal Involvement
(N = 61)
P
White blood cells G/L 7.3 (6.1; 8.9) 6.4 (5.3; 7.8) 0.001 7.1 (5.8; 8.8) 6.3 (5.1; 7.6) 0.001 7.0 (5.7; 9.7) 6.6 (5.5; 7.9) 0.56 6.6 (5.5; 7.9) 6.5 (5.1; 8.1) 0.58
Monocytes G/L 0.6 (0.5; 0.8) 0.6 (0.4; 0.7) <0.001 0.6 (0.5; 0.8) 0.5 (0.4; 0.6) <0.001 0.6 (0.4; 0.7) 0.6 (0.4; 0.7) 0.82 0.6 (0.5; 0.7) 0.6 (0.4; 0.7) 0.29
Neutrophils G/L 4.8 (3.5; 5.8) 3.8 (3.0; 4.8) <0.001 4.3 (3.5; 5.6) 3.7 (2.9; 4.6) <0.001 4.5 (3.7; 6.4) 4.0 (3.1; 5.0) 0.33 4.0 (3.1; 5.0) 3.9 (2.9; 5.1) 0.50
Eosinophils G/L 0.1 (0.1; 0.2) 0.2 (0.1; 0.3) 0.010 0.2 (0.1; 0.2) 0.2 (0.1; 0.3) 0.58 0.1 (0.1; 0.3) 0.2 (0.1; 0.2) 0.76 0.2 (0.1; 0.3) 0.1 (0.1; 0.2) 0.079
Lymphocytes G/L 1.6 (1.3; 2.3) 1.7 (1.2; 2.1) 0.75 1.6 (1.2; 2.3) 1.7 (1.2; 2.1) 0.34 1.7 (0.9; 2.2) 1.7 (1.2; 2.1) 0.67 1.7 (1.2; 2.1) 1.6 (1.3; 2.1) 0.73
Basophils G/L 0.0 (0.0; 0.1) 0.0 (0.0; 0.1) 0.47 0.0 (0.0; 0.1) 0.0 (0.0; 0.1) 0.26 0.0 (0.0; 0.1) 0.0 (0.0; 0.1) 0.47 0.0 (0.0; 0.1) 0.0 (0.0; 0.1) 0.62
Hemoglobin g/dL 13.1 (12.5; 14.0) 13.3 (12.5; 14.1) 0.69 13.1 (12.4; 14.0) 13.4 (12.5; 14.1) 0.47 12.1 (10.6; 13.2) 13.3 (12.5; 14.1) 0.016 13.3 (12.5; 14.0) 13.3 (12.8; 14.2) 0.24
Platelets G/L 264.0 (226.0; 311.0) 255.0 (215.0; 297.0) 0.33 265.0 (228.0; 307.0) 250.5 (210.0; 293.0) 0.14 236.0 (204.0; 276.0) 256.0 (216.0; 303.0) 0.24 257.0 (222.0; 305.0) 239.0 (200.0; 292.0) 0.14
CRP mg/L 3.0 (3.0; 6.0) 3.0 (3.0; 4.0) 0.064 3.0 (3.0; 6.0) 3.0 (3.0; 4.0) 0.003 3.0 (3.0; 5.0) 3.0 (3.0; 4.0) 0.85 3.0 (3.0; 5.0) 3.0 (3.0; 3.0) 0.24
ESR mm/h 9.0 (2.0; 19.0) 11.0 (6.0; 21.0) 0.34 11.0 (6.0; 22.0) 10.0 (6.0; 18.0) 0.62 11.0 (5.0; 32.0) 10.5 (6.0; 19.0) 0.52 11.0 (6.0; 19.0) 10.0 (6.0; 23.0) 0.79
NT pro BNP ng/L 105.5 (45.0; 309.0) 89.0 (55.0; 177.0) 0.31 98.0 (57.0; 281.0) 88.0 (53.0; 168.0) 0.26 608.5 (291.0; 1449) 89.5 (53.0; 185.5) <0.001 93.0 (57.0; 206.0) 76.0 (45.0; 161.0) 0.28
Ferritin ng/mL 76.0 (32.0; 160.0) 70.0 (33.0; 135.0) 0.51 78.0 (32.0; 143.0) 68.0 (33.0; 137.0) 0.67 32.5 (14.0; 56.0) 73.5 (34.0; 142.0) 0.046 64.0 (28.0; 132.0) 101.0 (73.0; 187.0) <0.001
Uric acid mg/L 48.0 (35.5; 57.0) 48.0 (39.0; 57.0) 0.42 48.0 (36.0; 57.0) 48.0 (40.0; 57.0) 0.50 59.0 (52.5; 72.5) 48.0 (38.0; 56.0) 0.012 48.0 (38.0; 56.0) 48.0 (41.0; 61.0) 0.17
AST UI/L 20.0 (17.0; 23.0) 22.0 (19.0; 26.0) 0.007 21.0 (18.0; 25.0) 22.0 (18.0; 26.0) 0.52 20.0 (18.0; 22.0) 22.0 (18.0; 26.0) 0.23 21.0 (18.0; 26.0) 22.0 (18.0; 25.0) 0.60
ALT UI/L 16.0 (11.0; 20.0) 16.0 (13.0; 22.0) 0.070 16.0 (12.0; 22.0) 15.5 (13.0; 21.0) 0.97 12.5 (9.0; 15.0) 16.0 (12.0; 21.5) 0.035 16.0 (12.0; 21.0) 17.0 (13.5; 22.0) 0.53
ALP UI/L 60.0 (51.0; 76.0) 65.0 (53.0; 86.0) 0.11 62.0 (52.0; 80.0) 66.0 (52.0; 85.0) 0.20 73.0 (56.0; 110.0) 64.0 (52.0; 83.0) 0.16 65.0 (52.0; 85.0) 63.0 (50.0; 81.5) 0.40
GGT UI/L 20.0 (12.0; 31.0) 21.0 (14.0; 39.0) 0.25 22.0 (15.0; 40.0) 20.0 (14.0; 36.0) 0.85 18.0 (14.0; 65.0) 21.0 (14.0; 37.0) 0.74 21.0 (14.0; 38.0) 20.0 (13.0; 39.0) 0.51
Total bilirubin mg/L 4.0 (3.0; 5.0) 4.0 (3.0; 5.0) 0.58 4.0 (3.0; 5.0) 4.0 (3.0; 5.0) 0.58 3.5 (3.0; 6.0) 4.0 (3.0; 5.0) 0.97 4.0 (3.0; 5.0) 4.0 (3.0; 6.0) 0.025
Serum sodium
mmol/L
140.0 (139.0; 142.0) 140.0 (139.0; 142.0) 0.51 140.0 (139.0; 141.0) 140.5 (139.0; 142.0) 0.11 139.5 (137.0; 141.0) 140.0 (139.0; 142.0) 0.33 140.0 (139.0; 142.0) 140.0 (138.0; 141.5) 0.17
Serum potassium
mmol/L
4.0 (3.9; 4.4) 4.2 (4.0; 4.4) 0.039 4.1 (3.9; 4.4) 4.2 (4.0; 4.4) 0.57 4.2 (3.8; 4.4) 4.2 (4.0; 4.4) 0.96 4.2 (4.0; 4.4) 4.1 (4.0; 4.4) 0.27
Urea g/L 0.3 (0.3; 0.4) 0.3 (0.3; 0.4) 0.88 0.3 (0.3; 0.4) 0.3 (0.3; 0.4) 0.75 0.4 (0.4; 0.5) 0.3 (0.3; 0.4) 0.003 0.3 (0.3; 0.4) 0.3 (0.3; 0.4) 0.33
Creatinin mg/L 8.0 (7.0; 9.0) 8.0 (7.0; 9.0) 0.70 8.0 (7.0; 9.0) 7.0 (7.0; 9.0) 0.21 9.0 (7.5; 10.5) 8.0 (7.0; 9.0) 0.039 8.0 (7.0; 9.0) 8.0 (7.0; 9.0) 0.90
A1globulins g/L 3.0 (2.7; 3.4) 2.9 (2.6; 3.2) 0.023 2.9 (2.7; 3.3) 2.8 (2.5; 3.2) 0.24 3.2 (2.8; 3.5) 2.9 (2.6; 3.2) 0.11 2.9 (2.6; 3.2) 2.9 (2.6; 3.2) 1.00
A2globulins g/L 7.8 (6.8; 8.4) 7.5 (6.9; 8.2) 0.31 7.7 (6.9; 8.4) 7.5 (6.8; 8.1) 0.36 7.6 (7.4; 9.0) 7.6 (6.8; 8.2) 0.43 7.6 (6.9; 8.3) 7.4 (6.5; 8.0) 0.12
Betaglobulins g/L 7.9 (7.3; 8.5) 7.7 (7.1; 8.4) 0.48 7.7 (7.2; 8.4) 7.7 (7.1; 8.4) 0.97 7.9 (7.5; 9.1) 7.7 (7.1; 8.4) 0.52 7.7 (7.1; 8.4) 7.7 (7.2; 8.4) 0.60
Gammaglobulins g/L 10.3 (7.8; 13.5) 9.8 (8.4; 11.6) 0.33 10.1 (8.0; 12.4) 9.8 (8.5; 11.9) 0.93 10.9 (10.5; 12.8) 9.9 (8.2; 12.0) 0.059 9.9 (8.2; 12.0) 10.1 (9.0; 12.8) 0.21
Albumin g/L 40.3 (38.0; 44.0) 41.0 (39.0; 43.0) 0.27 40.3 (38.0; 43.0) 41.0 (39.1; 43.0) 0.21 39.4 (37.2; 41.0) 41.0 (38.8; 43.0) 0.064 41.0 (38.5; 43.0) 41.1 (39.7; 44.0) 0.15

Values are presented as median (interquartile range [IQR]). dcSSc: diffuse cutaneous systemic sclerosis; lcSSc: limited cutaneous systemic sclerosis; ILD: interstitial lung disease; PH: pulmonary hypertension; SSc: systemic sclerosis; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; ALP: alkaline phosphatase; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: gammaglutamyltranspeptidase; NTproBNP: N-terminal pro-brain natriuretic peptide; G/L: Giga/Liter; A1 globulins: alpha 1 globulins; A2 globulins: Alpha 2 globulins; No: Non ILD, non PH, and non-gastrointestinal tract involvement; P: p value < 0.05 (significant results appear in bold in the table). * p values are adjusted for type of SSc.