Table 2.
Accuracy of the LIAISON® Meridian H. pylori SA test in treatment-naïve patients.
| Comparison SAT vs. UBT | Sensitivity (95% CI) |
Specificity (95% CI) |
PPV (95% CI) |
NPV (95% CI) |
LR+ (95% CI) |
LR− (95% CI) |
Global Accuracy (95% CI) |
AUC (95% CI) |
|---|---|---|---|---|---|---|---|---|
| Naïve | 74% (59–88) | 96% (92–100) | 89% (77–100) | 90% (84–96) | 19 (7–51) | 0.27 (0.16–0.45) | 90% (84–95) | 0.88 (0.80–0.96) |
| NDIRS naïve | 73% (54–92) | 93% (86–100) | 83% (65–100) | 89% (80–97) | 11 (4–29) | 0.29 (0.15–0.55) | 87% (80–95) | 0.86 (0.75–0.96) |
| IRMS naïve | 75% (51–99) | 100% (99–100) | 100% (96–100) | 92% (82–100) | - | 0.25 (0.11–0.58) | 93% (86–100) | 0.91 (0.79–1.0) |
SAT: stool antigen test; UBT: urea breath test; PPV: positive predictive value; NPV: negative predictive value; LR+: positive likelihood ratio; LR−: negative likelihood ratio; AUC: area under the ROC curve; IRMS: isotope ratio mass spectrometry, cut-off value 5‰; NDIRS: non-dispersive isotope-selective infrared spectrometry, cut-off value 2.5‰.