Table 4.
Adverse events during irinotecan plus fluorouracil/folinic acid (nal-IRI/FF) treatment.
| All Grade | Grade 3/4 | Required Dose Reduction |
Required Discontinuation | |||||
|---|---|---|---|---|---|---|---|---|
| No. | (%) | No. | (%) | |||||
| Hematologic | ||||||||
| Neutropenia | 25 | (63) | 11 | (28) | 9 | (23) | ||
| Leukocytopenia | 24 | (60) | 5 | (13) | ||||
| Thrombocytopenia | 11 | (28) | 0 | (0) | ||||
| Anemia | 14 | (35) | 2 | (5) | ||||
| Non-hematologic | ||||||||
| General fatigue | 25 | (63) | 9 | (23) | 9 | (23) | 6 | (15) |
| Anorexia | 16 | (40) | 2 | (5) | ||||
| Diarrhea | 11 | (28) | 1 | (3) | 2 | (5) | 1 | (3) |
| Hypokalemia | 2 | (5) | 0 | (0) | ||||
| Dysgeusia | 2 | (5) | 0 | (0) | ||||
| Hemobilia | 1 | (3) | 1 | (3) | ||||
| Septic shock | 1 | (3) | 1 | (3) | ||||
| Ileus | 1 | (3) | 1 | (3) | ||||
| Infusion reaction | 1 | (3) | 0 | (0) | ||||