Table 3.
Information about the eight potential binding sites (Cluster 1–Cluster 8) on RAS from FTMAP.
| Site | Consist | Location |
|---|---|---|
| Cluster 1 | R68, Q95, Y96, Q99, D92, E62, R68, D92, Q95, Y96, Q99, R102 | Between switch II and α3 |
| Cluster 2 | H94, L133, S136, Y137, F90, E91, I93, H94, L133, Y137 | Between α3 and α4 |
| Cluster 3 | S17, I21, Q25, H27, V29, D33, T35, D38, Y40 | Opposite to Switch I relative to gppnhp |
| Cluster 4 | F28, D30, K147 | Near L8 |
| Cluster 5 | A11, G12, N86, K88, S89, D92 | Between P-loop and N-terminus of α3 |
| Cluster 6 | D30, E31, Tyr32, GppNHp | Near N-terminus of switch I |
| Cluster 7 | L23, N26, K42, V44, V45, R149, E153, Y157 | Near C-terminus of α1 |
| Cluster 8 | G13, Y32, N86, K117, GppNHp | Between P-loop and switch I |