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Crystal structures of the 7 human sirtuins. The PDB identifiers for SIRT-1, SIRT-2, SIRT-3, SIRT-5, and SIRT-6 are 4KXQ, 4Y6O, 4BN4, 6LJK, and 6HOY, respectively. SIRT-4 and SIRT-7 do not exist in a crystal structure; thus, the AlphaFold-software-predicted structures are shown with the identifiers AF-A0A347ZJG7-F1 and AF-Q9NRC8-F1, respectively.
