Table 1.

Enzymatic activities and cellular localizations of the 7 sirtuins.

Sirtuin	Enzymatic Activity	Cellular Localization
SIRT-1	Deacetylase [7]	Nucleus, Cytoplasm [13,14]
SIRT-2	Deacetylase, Deacylase [13,15,16]	Nucleus, Cytoplasm [13,15]
SIRT-3	Deacetylase [17,18]	Mitochondria [17,18]
SIRT-4	Mono-ADP-ribosyltransferase, Lipoamidase [19,20]	Mitochondria [19]
SIRT-5	Deacylase, Desuccinylase, Demalonylase [21,22]	Mitochondria [23]
SIRT-6	Deacetylase, Deacylase, Mono-ADP-ribosyl transferase [24,25,26,27]	Nucleus [13,14]
SIRT-7	Deacetylase [19]	Nucleus (nucleolus) [13,14]