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. 2022 Aug 24;27(17):5384. doi: 10.3390/molecules27175384

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) The schematic representation of the insulin signaling promoting potential of resveratrol, grape seed extract [183], and epigallocatechin gallate (EGCG) [231]. (b) Developmental BPA exposure is associated with anxiogenic effects in juvenile rats via downregulating the expression of estrogen receptor beta (Esr2) and melanocortin receptors (Mc3r, Mc4r) in amygdala. The soy diet supplementation mitigated anxiogenic effects by upregulating these genes [235]. IRS: insulin receptor substrate; PI3K: phosphatidylinositol 3-kinase; Akt: protein kinase B.