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. 2022 Aug 29;27(17):5545. doi: 10.3390/molecules27175545

Figure 2.

Figure 2

Resveratrol treatment increases the expression of Sirt1, Sirt3 and FoxO in neonatal rat cardiomyocytes suffering H/R, while this effect was abrogated by EX527. (A) Effects of resveratrol on Sirt1 and Sirt3 activities of H/R injury cardiomyocytes were measured by microplate reader. (B) Cardiomyocytes lysates were subjected to Western blot analysis for Sirt1, Sirt3, FoxO1 and FoxO3a. (C) The mRNA expression of FoxO1 and FoxO3a in cardiomyocytes was detected by Real-Time PCR. Figures are representative images of three different samples. Results are expressed as mean ± S.D. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. control group; # p < 0.05, ## p < 0.01, ### p < 0.005 vs. H/R group; ∆ p < 0.05, ∆∆ p < 0.01, ∆∆∆ p < 0.001 vs. Res-20 group.