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. 2022 Aug 26;12(17):2948. doi: 10.3390/nano12172948

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic representation of specific targeted drug delivery strategy of Dox prodrug-loaded TNPHER2pep for HER2 overexpressing breast cancer cells. (A) Dissociation and association of expression of HER2 on epithelial cells within breast cancer lesions are many folds higher than that on healthy epithelial cells. On HER2 overexpressing breast cancer cells, TNPHER2pep liposome undergoes endocytosis (B) density of peptide and length of EG linker are designed, synthesized, and applied using both in vitro and in vivo methods to increase liposome cellular uptake in breast cancer cells. Reproduced with permission from ref. [86] Copyright © 2020, Elsevier.