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. 2022 Aug 25;27(17):5424. doi: 10.3390/molecules27175424

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PLGA-PTB-NPs reduces A. brasiliensis virulence in G. mellonella model. Survival curves of G. mellonella larvae (n = 10/strain) infected via injection with 2 × 10⁴ conidia from A. brasiliensis with free PTB. Larvae were monitored for 5 days post-infection. Statistical significance relative to control was judged by the Kaplan–Meier followed by Mantel–Cox log-rank tests. At least three independent biological replicates were carried out for each experiment. * p < 0.05 compared to the free PTB and PLGA-PTB-NPs; ** p < 0.01 compared to the free PTB and PLGA-PTB-NPs.