Table 1.

Release kinetics models applied [47].

Release Kinetic	Equation	Plot Representation
Zero-order	${\mathrm{C}}_{\mathrm{t}}={\mathrm{C}}_0+{\mathrm{K}}_0·\mathrm{t}$	cumulative % drug released vs. time
First order	${\log \mathrm{C}}_{\mathrm{t}}={\log \mathrm{C}}_0-{\mathrm{K}}_1·\frac{\mathrm{t}}{2.303}$	log cumulative %drug remaining vs. time
Higuchi model	${\mathrm{C}}_{\mathrm{t}}={\mathrm{K}}_{\mathrm{H}}· \sqrt{\mathrm{t}}$	cumulative % drug released vs. square root of time

C_t—drug released in time ‘t’; C₀—the initial amount of drug in dissolution medium (usually is 0); K₀—zero order release constant; K₁—first order release constant; K_H—Higuchi dissolution constant.