Table 2. Performance of menstrual blood for the detection of HPV infection or CIN lesion.
| Study | Wong et al [19] | Lee et al [20] | Budukh et al [18] | Wong et al [21] | Zhang et al [22] |
|---|---|---|---|---|---|
| Reference test | Pap test and colposcopy with histological confirmation | Histo-pathological test | Cervical HPV DNA test | Pap test and colposcopy with histological confirmation | Cervical HPV test by HPV GenoArray test |
| Sensitivity (%) | 82.8 % (in detection of CIN and condyloma acuminatum) |
88.9% (CIN 2+ for MCD 1 and 2) |
83.3% (in detection of CIN) |
83.0% (in detection of CIN or HPV infection) |
97.7% |
| Specificity (%) | 93.1% (in detection of CIN and condyloma acuminatum) |
50.0% (CIN 2+ for MCD 1 and 2) |
95.1% (in detection of CIN) |
98.0% (in detection of CIN or HPV infection) |
Not reported |
| PPVa | 90.0% (in detection of CIN and condyloma acuminatum) |
61.5% (CIN 2+ for MCD 1 and 2) |
Not reported |
99.0% (in detection of CIN or HPV infection) |
Not reported |
| NPVb | 87.9% (in detection of CIN and condyloma acuminatum) |
83.3% (CIN 2+ for MCD 1 and 2) |
Not reported | 74.0% (in detection of CIN or HPV infection) |
Not reported |
a
PPV, Positive predictive value
b
NPV, Negative predictive value