Table 4.
Characteristics of oncolytic viruses.
| DNA | RNA | |||||
|---|---|---|---|---|---|---|
| Adenovirus | Herpesvirus | Vaccinia virus | Measles virus | Reovirus | Picornavirus | |
| Genome structure and size | dsDNA 26-45 kb |
dsDNA 120-240 kb |
dsDNA 130-280 kb |
ss (-) RNA 15.2-15.9 kb |
dsRNA 18.2 - 30.5 kb |
ss (+) RNA 7-8 kb |
|
Virion Capsid
Symmetry |
Naked Icosahedral | Enveloped Icosahedral |
Enveloped Complex |
Enveloped Helical |
Naked Icosahedral |
Naked Icosahedral |
|
Transgene
capacity |
++ | +++ | +++ | + | + | + |
| In vivo gene expression | +++ | +++ | +++ | ++ | ++ | ++ |
| Immunogenicity | +++ | +++ | ++ | ++ | ++ | + |
| Stability | ++ | ++ | ++ | + | + | + |
| Selectivity | +++ | ++ | ++ | ++ | ++ | ++ |
| Safety | +++ | ++ | ++ | ++ | ++ | ++ |
| Viral yield | +++ | + | ++ | +++ | + | + |
| Systemic delivery | - | - | + | + | + | + |