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. 2022 Sep 1;2022:4722647. doi: 10.1155/2022/4722647

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Copyright © 2022 Binbin Yan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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SIRT3 expression is downregulated in the spinal cords of mice with neuropathic pain. (a) SNI surgical procedures. (b) Mechanical withdrawal threshold (MWT) in ipsilateral paw and contralateral paw of SNI and Sham group mice before and 3, 7, 14, and 21 d after surgery (n =9. ^∗∗P < 0.01 vs Sham ipsilateral paw). (c) Cold allodynia score (n =9. ^∗∗P < 0.01 vs Sham ipsilateral paw). (d) Western blots for SIRT3 protein (n =8. ^∗∗P < 0.01 vs Sham). (e) Real-time quantitative PCR for SIRT3 mRNA (n =8. ^∗∗P < 0.01 vs Sham). All data are expressed as mean ± SD.