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Overexpression of spinal SIRT3 attenuates pain behaviors in the ipsilateral paw of SNI mice. (a) Experimental schedule. (b) Intrathecal injection illustration. (c, d) Protein and mRNA levels of SIRT3 (n = 8). (e, f) Mechanical pain and cold pain thresholds in the ipsilateral paw of mice (n = 17~18). (g, h) Mechanical pain and cold pain thresholds in the contralateral paw of mice (n = 17~18). All data are expressed as mean ± SD. ∗∗P < 0.01 vs Sham + LV-NC; ##P < 0.01 vs SNI + LV-NC.
