Figure 2.

Melatonin protects the viability of HEI-OC1 cells. (a) Real-time cell proliferation of the four groups. The control group (green curve), the cisplatin group (black curve), the melatonin group (brown curve), the melatonin pretreatment group (purple curve). (b) The bar graph shows quantification of the results, each value represents the average of three independent experiments. MTS assay revealed that cisplatin inhibited cell viability, and melatonin had a protective effect on cisplatin cytotoxicity, ∗∗∗p < 0.001.