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. 2022 Sep 1;2022:7160816. doi: 10.1155/2022/7160816

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Copyright © 2022 Na Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Melatonin attenuates cisplatin-induced apoptosis in HEI-OC1 cells. (a) The morphological characteristics of HEI-OC1 cells were compared using the TUNEL assay. The green fluorescence within the nucleus represented DNA breakage. Cells in the cisplatin group display obvious apoptotic features. Fewer cells show these apoptotic characteristics in the cisplatin exposure after melatonin pretreatment group, bar = 20 μm. (b) TUNEL assay showed a significant increase in the apoptosis rate of the cisplatin group. After melatonin pretreatment, the apoptosis rate decreased, ∗∗p < 0.01.