Table 2.
Efficacy data.
| Variable | Kangbingdu liquid | Placebo | Difference (95%CI) | P value |
|---|---|---|---|---|
| Primary outcome | n = 1986 | n = 661 | ||
| Total- scores | 8.5 (8.3 to 8.7) | 8.4 (8.1 to 8.7) | ||
| Total scores on day 5, mean(95%CI) | 1.10 (1.00 to 1.20) | 2.05 (1.82 to 2.28) | ||
| Change on day 5, adjusted mean(95%CI) | 7.39 (7.26 to 7.51) | 6.43 (6.24 to 6.62) | 0.96 (0.75 to 1.16) | <0.0001 |
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| Secondary outcomes | ||||
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| Aversion to wind | n = 830 (%) | n = 281 (%) | ||
| Symptom resolution rate on day 2 | 275 (33.13) | 63 (22.42) | −10.71 (−16.55 to -−4.88) | 0.0007 |
| Symptom resolution rate on day 3 | 500 (60.24) | 151 (53.74) | −6.5 (−13.22 to 0.21) | 0.0557 |
| Symptom resolution rate on day 4 | 672 (80.96) | 204 (72.60) | −8.37 (-14.23 to −2.51) | 0.0030 |
| Symptom resolution rate on day 5 | 754 (90.84) | 228 (81.14) | −9.7 (−14.68 to −4.73) | < 0.0001 |
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| Aversion to cold | n = 912 (%) | n = 304 (%) | ||
| Symptom resolution rate on day 2 | 353 (38.71) | 74 (24.34) | −14.36 (−20.13 to −8.6) | < 0.0001 |
| Symptom resolution rate on day 3 | 606 (66.45) | 156 (51.32) | −15.13 (−21.53 to −8.73) | < 0.0001 |
| Symptom resolution rate on day 4 | 758 (83.11) | 219 (72.04) | −11.07 (−16.67 to −5.47) | < 0.0001 |
| Symptom resolution rate on day 5 | 843 (92.43) | 258 (84.87) | −7.57 (−11.94 to −3.19) | < 0.0001 |
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| Fever | n = 805 (%) | n = 267 (%) | ||
| Symptom resolution rate on day 2 | 321 (39.88) | 63 (23.60) | −16.28 (−22.39 to −10.17) | < 0.0001 |
| Symptom resolution rate on day 3 | 563 (69.94) | 137 (51.31) | −18.63 (-25.41 to −11.85) | < 0.0001 |
| Symptom resolution rate on day 4 | 700 (86.96) | 205 (76.78) | −10.18 (−15.75 to −4.6) | < 0.0001 |
| Symptom resolution rate on day 5 | 766 (95.16) | 230 (86.14) | −9.01 (−13.41 to −4.61) | < 0.0001 |
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| Cough | n = 1163 (%) | n = 410 (%) | ||
| Symptom resolution rate on day 2 | 225 (19.35) | 49 (11.95) | −7.4 (−11.27 to −3.52) | 0.0007 |
| Symptom resolution rate on day 3 | 425 (36.54) | 102 (24.88) | −11.67 (−16.68 to −6.65) | < 0.0001 |
| Symptom resolution rate on day 4 | 614 (52.79) | 168 (40.98) | −11.82 (−17.38 to −6.26) | < 0.0001 |
| Symptom resolution rate on day 5 | 833 (71.63) | 229 (55.85) | −15.77 (−21.23 to −10.31) | < 0.0001 |
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| Stuffy | n = 1318 (%) | n = 415 (%) | ||
| Symptom resolution rate on day 2 | 288 (21.85) | 47 (11.33) | −10.53 (−14.3 to −6.75) | < 0.0001 |
| Symptom resolution rate on day 3 | 591 (44.84) | 139 (33.49) | −11.35 (−16.62 to −6.07) | < 0.0001 |
| Symptom resolution rate on day 4 | 876 (66.46) | 228 (54.94) | −11.52 (−16.95 to −6.1) | < 0.0001 |
| Symptom resolution rate on day 5 | 1133 (85.96) | 295 (71.08) | −14.88 (−19.63 to −10.13) | < 0.0001 |
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| Runny nose | n = 1392 (%) | n = 473 (%) | ||
| Symptom resolution rate on day 2 | 317 (22.77) | 62 (13.11) | −9.67 (−13.42 to −5.91) | < 0.0001 |
| Symptom resolution rate on day 3 | 639 (45.91) | 161 (34.04) | −11.87 (−16.88 to −6.86) | < 0.0001 |
| Symptom resolution rate on day 4 | 927 (66.59) | 244 (51.59) | −15.01 (−20.15 to −9.87) | < 0.0001 |
| Symptom resolution rate on day 5 | 1150 (82.61) | 326 (68.92) | −13.69 (−18.31 to −9.07) | < 0.0001 |
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| Sore throat | n = 1430 (%) | n = 475 (%) | ||
| Symptom resolution rate on day 2 | 301 (21.05) | 64 (13.47) | −7.58 (−11.3 to −3.85) | 0.0003 |
| Symptom resolution rate on day 3 | 613 (42.87) | 152 (32.00) | −10.87 (−15.78 to −5.95) | < 0.0001 |
| Symptom resolution rate on day 4 | 928 (64.90) | 252 (53.05) | −11.84 (−16.97 to −6.72) | < 0.0001 |
| Symptom resolution rate on day 5 | 1183 (82.73) | 330 (69.47) | −13.25 (−17.84 to −8.67) | < 0.0001 |
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| Muscular soreness | n = 910 (%) | n = 290 (%) | ||
| Symptom resolution rate on day 2 | 356 (39.12) | 66 (22.76) | −16.36 (−22.14 to −10.59) | < 0.0001 |
| Symptom resolution rate on day 3 | 579 (63.63) | 148 (51.03) | −12.59 (−19.14 to −6.04) | 0.0001 |
| Symptom resolution rate on day 4 | 757 (83.19) | 211 (72.76) | −10.43 (−16.1 to −4.76) | < 0.0001 |
| Symptom resolution rate on day 5 | 834 (91.65) | 237 (81.72) | −9.92 (−14.72 to −5.13) | < 0.0001 |
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| Headache | n = 1029 (%) | n = 338 (%) | ||
| Symptom resolution rate on day 2 | 427 (41.50) | 94 (27.81) | −13.69 (−19.33 to −8.04) | < 0.0001 |
| Symptom resolution rate on day 3 | 675 (65.60) | 204 (60.36) | −5.24 (−11.21 to 0.73) | 0.0809 |
| Symptom resolution rate on day 4 | 847 (82.31) | 252 (74.56) | −7.76 (−12.95 to −2.56) | 0.0018 |
| Symptom resolution rate on day 5 | 947 (92.03) | 277 (81.95) | −10.08 (−14.5 to −5.66) | < 0.0001 |
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| Fatigue | n = 1160 (%) | n = 394 (%) | ||
| Symptom resolution rate on day 2 | 395 (34.05) | 79 (20.05) | −14 (−18.8 to −9.2) | < 0.0001 |
| Symptom resolution rate on day 3 | 702 (60.52) | 173 (43.91) | −16.61 (−22.26 to −10.96) | < 0.0001 |
| Symptom resolution rate on day 4 | 874 (75.34) | 259 (65.74) | −9.61 (−14.91 to −4.31) | 0.0002 |
| Symptom resolution rate on day 5 | 1019 (87.84) | 301 (76.40) | −11.45 (−16.04 to −6.85) | < 0.0001 |
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| Sweat | n = 557 (%) | n = 176 (%) | ||
| Symptom resolution rate on day 2 | 255 (45.78) | 61 (34.66) | −11.12 (−19.28 to −2.96) | 0.0094 |
| Symptom resolution rate on day 3 | 404 (72.53) | 102 (57.95) | −14.58 (−22.76 to −6.4) | 0.0003 |
| Symptom resolution rate on day 4 | 482 (86.54) | 128 (72.73) | −13.81 (−20.97 to −6.64) | < 0.0001 |
| Symptom resolution rate on day 5 | 503 (90.31) | 141 (80.11) | −10.19 (−16.58 to −3.8) | 0.0003 |
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| Time for body temperature to return to normal | n = 579 | n = 196 | ||
| P25 (95%CI) | 28.00 (25.37 to 31.50) | 35.34 (26.00 to 43.17) | 0.0022 | |
| P50 (95%CI) | 48.33 (46.00 to 52.50) | 64.59 (51.08 to 70.50) | ||