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. 2022 Sep 7;154(10):e202213084. doi: 10.1085/jgp.202213084

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© 2022 Nourse et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 1. — Histological analysis reveals abnormalities in the developing brain of Piezo1 KO mutant mice. (A) Representative H&E stains of E10.5 WT (left) and Piezo1 KO (right) littermate embryo sections. FB, forebrain; MB, midbrain; HB, hindbrain. Regions marked by red and blue boxes are shown at higher magnification in B and C. (B–D) Representative images highlighting differences in neuroepithelial thickness (B), inner/apical and outer/basal border morphology (C and D), and pseudostratified layering (D) between E10.5 WT (top row) and Piezo1 KO (bottom row) littermates. Purple box in C highlights the abnormal undulations at the basal border in the mutant. Images in A–D are representative of n = 7 embryos for WT and for Piezo1 KO. Scale bar in D also applies to B and C.