TABLE 3.
Univariable and multivariable analysis of progression‐free survival
| Variable | No. of events/patients | Univariable analysis | Multivariable analysis a | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p‐value | Hazard ratio (95% CI) | p‐value | ||
| Treatment setting | .004 | .031 | |||
| First line | 6/14 | 1 | 1 | ||
| Refractory | 36/39 | 3.68 (1.54, 8.81) | 3.38 (1.20, 9.48) | ||
| Relapsed | 19/22 | 2.56 (1.02, 6.42) | 3.58 (1.17, 11.01) | ||
| Age at ICE treatment, years | .459 | ||||
| ≤60 | 49/60 | 1 | |||
| >60 | 12/15 | 1.28 (0.68, 2.42) | |||
| Gender | .160 | ||||
| Male | 50/58 | 1 | |||
| Female | 11/17 | 0.64 (0.33, 1.23) | |||
| Race | .502 | ||||
| Chinese | 50/58 | 1 | |||
| Non‐Chinese | 11/17 | 0.80 (0.42, 1.55) | |||
| Histology | .527 | .031 | |||
| Non‐NKTCL | 49/60 | 1 | 1 | ||
| NKTCL | 12/15 | 1.23 (0.65, 2.33) | 2.61 (1.09, 6.21) | ||
| Stage at diagnosis | .004 | .057 | |||
| 1–2 | 8/14 | 1 | 1 | ||
| 3–4 | 53/61 | 2.72 (1.28, 5.79) | 2.29 (0.92, 5.70) | ||
| B symptoms | .183 | ||||
| Yes | 10/16 | 0.64 (0.32, 1.28) | |||
| No | 48/56 | 1 | |||
| LDH | .068 | ||||
| Elevated | 24/27 | 2.04 (0.91, 4.55) | |||
| Normal | 8/15 | 1 | |||
| Extranodal involvement | .275 | ||||
| Yes | 47/58 | 1.43 (0.74, 2.76) | |||
| No | 11/14 | 1 | |||
| ECOG performance status | .118 | ||||
| 0–1 | 43/56 | 1 | |||
| 2 | 2/2 | 4.09 (0.92, 18.15) | |||
| IPI | .019 | ||||
| Low, low‐intermediate | 5/11 | 1 | |||
| High‐intermediate, high | 12/14 | 3.34 (1.15, 9.71) | |||
| Complete response (CR) | <.001 | .001 | |||
| No | 41/45 | 3.76 (2.13, 6.63) | 2.76 (1.52, 5.00) | ||
| Yes | 20/30 | 1 | 1 | ||
Note: For multivariable analysis, all variables were included in the best subsets selection procedure except for LDH, ECOG performance status and IPI. Treatment setting was forced in the model and not subjected to variable selection.
a
No. of events/patients for multivariable analysis = 57/71.