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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Hypertension. 2022 Aug 1;79(10):2127–2137. doi: 10.1161/HYPERTENSIONAHA.122.18558

Figure 2. Ligands and cardiovascular phenotypes of SCFAs GPCR receptors, as well as sites of expression which have been suggested to contribute to these phenotypes.

Figure 2.

This figure summarizes current knowledge regarding the ligands and sites of expression for GPR41, GPR43, GPR109A, OLFR78, and OLFR558. In addition, cardiovascular phenotypes in KO mice are outlined. Gpr41 KO mice exhibit increased SBP103, with higher pulse pressure, end-diastolic pressure (DP), tau, and perivascular fibrosis108. Gpr43 KO mice have an increased heart/body weight, pulse pressure, and perivascular fibrosis108. Gpr109a KO mice are reported to have a higher pulse pressure, end-DP, as well as perivascular fibrosis108. Olfr78 KO mice have a lower plasma renin activity39,49. Images in this figure are from Servier Medical Art (smart.servier.com).