Table 1.
Baseline characteristics of the CKiD Cohort by urine uromodulin to creatinine (mg/g) quartiles.
| Characteristic | Median [IQR] or n (%) | |||
|---|---|---|---|---|
| Uromodulin, mg/g Cr | <0.048 (n=109) |
[0.048, 0.118) (n=109) |
[0.118, 0.225) (n=109) |
≥0.225 (n=109) |
| Age, years | 14.3 [12.0, 16.0] | 13.9 [11.4, 15.9] | 11.8 [8.9, 14.5] | 8.8 [5.6, 10.8] |
| Male sex | 65 (60%) | 61 (56%) | 65 (60%) | 66 (61%) |
| Black race | 22 (20%) | 17 (16%) | 14 (13%) | 22 (20%) |
| Hispanic ethnicity | 12 (11%) | 15 (14%) | 18 (17%) | 18 (17%) |
| Glomerular diagnosis | 42 (39%) | 37 (34%) | 23 (21%) | 17 (16%) |
| Duration of CKD, years | 9.7 [4.1, 14.2] | 11.4 [6.6, 14.6] | 9.6 [6.0, 12.7] | 6.9 [4.3, 9.6] |
| U25eGFR, ml/min|1.73m2 | 53 [35, 71] | 45 [31, 61] | 49 [36, 59] | 51 [41, 64] |
| Weight, kg | 52 [39, 66] | 50 [34, 65] | 40 [29, 53] | 28 [19, 39] |
| Weight z-score | 0.2 [−0.6, 1.1] | 0.3 [−0.6, 1.0] | 0.1 [−0.8, 0.9] | −0.1 [−0.9, 1.0] |
| Height, cm | 159 [145, 167] | 156 [141, 167] | 143 [129, 157] | 127 [112, 141] |
| Height z-score | −0.5 [−1.3, 0.3] | −0.3 [−1.1, 0.4] | −0.8 [−1.4, 0.0] | −0.7 [−1.4, 0.0] |
| BMI | 20 [18, 25] | 20 [18, 24] | 19 [16, 23] | 17 [16, 20] |
| BMI z-score | 0.6 [−0.4, 1.4] | 0.4 [−0.2, 1.2] | 0.5 [−0.3, 1.4] | 0.4 [−0.2, 1.3] |
| Birth weight, kg | 3.2 [2.8, 3.6] | 3.2 [2.7, 3.6] | 3.2 [2.8, 3.6] | 3.2 [2.7, 3.6] |
| Low birth weight | 15 (15%) | 19 (19%) | 15 (15%) | 21 (21%) |
| Hypertension | 20 (19%) | 21 (20%) | 24 (23%) | 25 (24%) |
| Antihypertensive meds | 75 (69%) | 79 (72%) | 69 (63%) | 75 (69%) |
| Diuretic meds | 7 (6%) | 11 (10%) | 6 (6%) | 8 (7%) |
| Loop diuretics | 4 (4%) | 3 (3%) | 0 (0%) | 2 (2%) |
| Sodium intake, g/day | 3.1 [2.4, 4.2] | 3.4 [2.3, 5.0] | 2.9 [2.2, 4.0] | 3.1 [2.2, 3.8] |
| Clinic BP | ||||
| Systolic BP (mmHg) | 111 [103, 118] | 108 [100, 120] | 106 [98, 116] | 104 [97, 111] |
| Systolic BP z-score | 0.2 [−0.6, 0.8] | 0.2 [−0.4, 0.8] | 0.2 [−0.4, 1.2] | 0.6 [0.0, 1.3] |
| Diastolic BP (mmHg) | 68 [61, 75] | 63 [57, 73] | 63 [59, 73] | 64 [59, 71] |
| Diastolic BP z-score | 0.4 [−0.3, 1.2] | 0.0 [−0.7, 0.7] | 0.2 [−0.3, 1.1] | 0.6 [−0.1, 1.3] |
| ABPM | ||||
| 24-hour mean systolic BP (mmHg) | 115 [108, 122] | 113 [107, 121] | 111 [103, 118] | 109 [100, 116] |
| Systolic percent dipping | 11.8 [8.5, 14.6] | 11.8 [9.5, 15.1] | 11.4 [7.9, 14.3] | 11.6 [7.9, 15.2] |
| 24-hour mean diastolic BP (mmHg) | 67 [62, 72] | 67 [61, 73] | 66 [61, 72] | 65 [61, 71] |
| Diastolic percent dipping | 18.0 [14.1, 22.6] | 17.9 [14.4, 22.7] | 17.7 [13.5, 20.2] | 17.9 [12.0, 21.0] |
| Inadequate dipping (Systolic or Diastolic dip < 10%) | 39 (36%) | 40 (37%) | 45 (41%) | 46 (42%) |
| BP category | ||||
| Normotensive | 44 (42%) | 41 (39%) | 40 (38%) | 34 (32%) |
| Masked hypertension | 42 (40%) | 42 (40%) | 40 (38%) | 46 (44%) |
| White coat hypertension | 1 (1%) | 4 (4%) | 4 (4%) | 5 (5%) |
| Confirmed hypertension | 19 (18%) | 17 (16%) | 20 (19%) | 20 (19%) |
Abbreviations: IQR, interquartile range; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; BMI, body mass index; BP, blood pressure; ABPM, ambulatory blood pressure monitoring.