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. Author manuscript; available in PMC: 2022 Sep 9.
Published in final edited form as: Biomed Pharmacother. 2022 Jun 17;153:113277. doi: 10.1016/j.biopha.2022.113277

Fig. 5.

Fig. 5.

L-NAC reverses the adverse effects of fentanyl infusion on inspiratory and expiratory drives. Acutal values of inspiratory drive (TV/Ti) (Panel A) and expiratory drive (TV/Te) (Panel B) before (Pre), and during continuous intravenous infusion of fentanyl (1 μg/kg/min) and following two bolus intravenous injections of vehicle (VEH) or N-acetyl-L-cysteine (L-NAC, 500 μmol/kg) given at 60 and 90 min after start of fentanyl infusion in two groups of unanesthetized rats. There were 6 rats in the VEH group and 6 rats in the L-NAC group. The data are presented as mean ± SEM.