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. Author manuscript; available in PMC: 2022 Sep 9.
Published in final edited form as: Biomed Pharmacother. 2022 Jun 17;153:113277. doi: 10.1016/j.biopha.2022.113277

Fig. 7.

Fig. 7.

The first injection of L-NAC reverses many adverse effects of continuous fentanyl infusion on ventilatory parameters. A summary of total (cumulative) changes in Freq, TV, MV, Ti, Te, Ti/Te, EIP, EEP (Panel A), PIF, PEF, PIF/PEF, EF50, InspD, ExpD, NEBI (Panel B), and apneic pause and Te-RT (Panel C) during the 30 min period after the first IV injection of vehicle or N-acetyl-L-cysteine (L-NAC, 500 μmol/kg) in rats receiving a continuous infusion of fentanyl (1 μg/kg/min, IV). There were 6 rats in each group. Data are presented as mean ± SEM. *P < 0.05, significant change from Pre-values. †P < 0.05, L-NAC versus Pre.