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. 2022 Sep 8;8(1):71. doi: 10.1038/s41537-022-00280-6

Fig. 1. Maternal dexamethasone exposure induces sex-different behaviors in offspring.

Fig. 1

A Maternal dexamethasone exposure regimen: Dexamethasone (50 µg/kg) was subcutaneously injected into dams between gestational days 16 and 18, and a series of behavioral assessments were conducted on the offspring. B The 4 W PN-DEX-F showed increased immobility time in the TST. C No change in sucrose consumption was observed in any experimental group. D All experimental groups showed intact sensory gating functions at 3, 6, and 12 dB. E The 10 W PN-DEX-F showed increased immobility time in the TST and (F) FST. G, H 10 W PN-DEX-F showed increased dwelling time in the dark area in the LD test. I No significant changes were observed between sucrose consumption in the 10 W PN-DEX group and the 10 W Veh group. J, K 10 W PN-DEX-M showed significantly impaired sensory gating function in PPI but not in startle amplitude. L 10 W PN-DEX-M showed impaired LI. M, N Locomotor activity after amphetamine injection was increased. Data are presented as mean ± standard error of the mean (SEM). For the TST, FST, LD, SPT, and locomotor activity, an unpaired t test was conducted. *p < 0.05; **p < 0.01 compared with the Veh-M and Veh-F independently. For PPI and LI, two-way ANOVA followed by Tukey’s post-test was conducted; #p < 0.05, ##p < 0.01.