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. 2022 Sep 8;12:15206. doi: 10.1038/s41598-022-19538-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Prevalence of the countries of origin most indicative for the p.Glu148Gln variant: Countries that were found to be the most positively (A) and negatively (B) associated origins for a patient who carries a positive p.Glu148Gln variant. Red and blue bars represent the patients who carry and do not carry the p.Glu148Gln variant, respectively. The X-axis indicates the amount of grandparents from the four countries (0 being none, 1 being all four).