Table 3.
Comparisons of grayscale IVUS, VH-IVUS data, and MACEs between the low and high apo-C3 groups.
| Low apo-C3 group (≤ 8.5 mg/dL, n = 52) | High apo-C3 group (> 8.5 mg/dL, n = 46) | P-value | |
|---|---|---|---|
| Gray-scale data | |||
| Vessel volume (mm3) | 789.0 ± 87.9 | 806.9 ± 66.1 | 0.8731 |
| Plaque volume (mm3) | 480.2 ± 35.4 | 316.7 ± 27.1 | 0.8868 |
| Lumen volume (mm3) | 308.8 ± 54.3 | 480.2 ± 54.3 | 0.8633 |
| %Plaque burden (%) | 60.9 ± 0.9 | 61.1 ± 1.3 | 0.8655 |
| Length (mm) | 54.8 ± 0.9 | 55.6 ± 0.8 | 0.5658 |
| VH-IVUS data | |||
| FI volume | 179.7 ± 23.1 | 182.3 ± 18.9 | 0.9321 |
| FF volume | 84.5 ± 12.6 | 65.4 ± 6.9 | 0.2028 |
| NC volume | 48.2 ± 5.9 | 58.9 ± 8.3 | 0.2884 |
| DC volume | 15.8 ± 1.5 | 19.1 ± 2.4 | 0.2328 |
| %FI | 54.8 ± 0.9 | 55.0 ± 0.9 | 0.5658 |
| %FF | 24.1 ± 1.2 | 20.2 ± 1.0 | 0.0172* |
| %NC | 15.0 ± 0.7 | 17.9 ± 0.7 | 0.0143* |
| %DC | 6.1 ± 0.5 | 6.8 ± 0.5 | 0.5982 |
| MACEs | |||
| Total MACE (%) | 7 (13.5) | 19 (41.3) | 0.0018* |
| AMI (%) | 1 (1.9) | 1 (2.2) | 0.9302 |
| UAP (%) | 3 (5.8) | 2 (4.3) | 0.7496 |
| Cardiac death (%) | 0 (0) | 1 (2.2) | 0.2852 |
| Restenosis (%) | 2 (3.8) | 3 (6.5) | 0.5480 |
| New lesion (%) | 3 (5.8) | 18 (39.1) | < 0.001* |
| EVT (%) | 0 (0) | 2 (4.3) | 0.1287 |
Values are presented as mean ± standard errors or as numbers (percentages) of patients. *P < 0.05.
apo-C3 Apolipoprotein C3; IVUS Intravascular ultrasound; VH-IVUS Virtual histology-intravascular ultrasound; FI Fibrous; FF FIbrofatty; NC Necrotic core; DC Dense calcium; %FI Percentage of the FI volume in the plaque volume; %FF Percentage of the FF volume in the plaque volume; %NC Percentage of the NC volume in the plaque volume; %DC Percentage of the DC volume in the plaque volume; MACE Major cardiovascular event (defined in the manuscript); AMI Acute myocardial infarction; UAP Unstable angina pectoris; EVT Endovascular therapy; CI Cerebral infarction.