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. 2022 Sep 8;12:15205. doi: 10.1038/s41598-022-19670-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Polyamine pathway and urea cycle. (A) The polyamine pathway in mammalian cells (33,586,680 Fig. 1) ARG1: arginase1, ARG2 arginase2, ODC ornithine decarboxylase, SRM spermidine synthase, SMS spermine synthase, SMOX spermine oxidase, AZIN1 antizyme inhibitor 1, OAZ1 ornithine decarboxylase antizyme 1, SSAT1 spermidine/spermine N1-acetyltransferase 1, NOS nitric oxide synthase, ASL argininosuccinate lyase, ASS argininosuccinate synthase. (B) Urea cycle (31,978,055 Fig. 1) NAG N-acetyl glutamate, NAGS N-acetylglutamate synthase, CPS1 carbamoyl phosphate synthetase I, OAT ornithine aminotransferase, ornithine aminotransferase, ODC1 ornithine decarboxylase 1, OTC ornithine transcarbamylase.