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. 2022 Aug 26;13:959938. doi: 10.3389/fphar.2022.959938

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Copyright © 2022 Han, Cheng, Zhang, Fang, Yao, Zhu, Xiu, Jin, Lu, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myricetin-induced pyroptosis is associated with the endoplasmic reticulum. (A) Expression of mitochondrial-associated proteins (Bcl-2, Bax, and Cytochrome (C) after myricetin treatment and their corresponding statistical analyses. Expression of ER-associated proteins (Caspase-12 and Bip) after myricetin treatment and its statistical analysis. (B) Laser confocal microscope image of Ca²⁺staining after NCI-H446 cells treated with myricetin. (C) Analysis of ROS after NCI-H446 cells treated with myricetin. The results are presented as mean ± standard deviation (**p < 0.01, ***p < 0.001, ****p < 0.0001).