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. 2022 Aug 26;13:959938. doi: 10.3389/fphar.2022.959938

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Copyright © 2022 Han, Cheng, Zhang, Fang, Yao, Zhu, Xiu, Jin, Lu, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The antitumor effect of myricetin in vivo. Myricetin was intratumorally injected to the mice every 2 days for 2 weeks. Body weight (A), images of xenografted tumors (B), and tumor volumes (B) were recorded. (C) Analysis of Ki67 and immunohistochemistry (cleaved-caspase-3 and GSDME) results from tumor samples. (D) Western blot analyses of GSDME from tumor samples and its corresponding statistical analysis. The results were presented as mean ± standard deviation (**p < 0.01, ***p < 0.001, when compared with the Mock).