Figure 1.

Role of SIRT1/6/7 in bone remodeling. In BMSCs, SIRT1, SIRT6, and SIRT7 promote osteogenic differentiation by regulating transcription factors FoxO3, β-catenin, Runx2, Osx, and PPARγ. In pre-osteoblasts, SIRT6 not only regulates Runx2 and Osx transcription, but also inhibits DKK1 transcription, activates canonical Wnt signaling, and promotes osteogenic differentiation. In BMMs, SIRT1 inhibits osteoclast differentiation by regulating FoxO and TNF-α transcription, which results in ROS scavenging.