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. 2022 Aug 26;13:905564. doi: 10.3389/fphar.2022.905564

TABLE 3.

Differences between PI-IBS and non-PI-IBS.

Variable All (n = 8,256) p-value
PI-IBS n = 1,441 (%) Non-PI-IBS n = 6,815 (%)
Sex 0.011
 Female 1,117 (77.5) 5,484 (80.5)
 Male 324 (22.5) 1,331 (19.5)
Age (years) <0.001
 Mean (SD) 53.27 (7.614) 54.76 (7.722)
 Median (IQR) 53 (47, 59.5) 55 (49, 61)
Townsend Deprivation Score <0.001
 Mean (SD) −0.98 (3.168) −1.56 (2.918)
 Median (IQR) −1.76 (−3.48, 0.96) −2.35 (−3.73, 0.13)
 Missing data 2 (0.1) 11 (0.2)
Ever been offered/sought treatment for anxiety <0.001
 Yes 698 (48.4) 2,916 (42.8)
 No 741 (51.4) 3,867 (56.7)
 Missing data 2 (0.1) 32 (0.5)
Ever been offered/sought treatment for depression <0.001
 Yes 726 (50.4) 3,017 (44.3)
 No 711 (49.3) 3,767 (55.3)
 Missing data 4 (0.3) 31 (0.5)
Family history of IBS 0.002
 Yes 574 (39.8) 2,382 (35.0)
 No 509 (35.3) 2,629 (38.6)
 Missing data 358 (24.8) 1,804 (26.5)
Long-term/recurrent antibiotics as child or teenager <0.001
 Yes 496 (34.4) 1,619 (23.8)
 No 712 (49.4) 4,162 (61.1)
 Missing data 233 (16.2) 1,034 (15.2)
Diagnosed with coeliac disease or gluten sensitivity <0.001
 Yes 139 (9.6) 395 (5.8)
 No 1,246 (86.5) 6,264 (91.9)
 Missing data 56 (3.9) 156 (2.3)
PHQ-12 Score <0.001
 ≤6 271 (18.8) 2,043 (30.0)
 >6 1,097 (76.1) 4,433 (65.0)
 Missing data 73 (5.1) 339 (5.0)

Data were mean (SD) or n (%) unless noted otherwise. The distribution of age and the Townsend Deprivation Score is non-normal; therefore, the mean (SD) and median (P25 and P75) are used to describe. The p-value was calculated by the chi-square test and Wilcoxon’s rank-sum test where applicable. In this analysis, “Do not know,” “Prefer not to answer,” and “missing” were coded as missing data.