FIGURE 2.

[³H]CP55,940 displacement from hCB1R CHO cell membranes. Compound activity was quantified for [³H]CP55,940 binding in CHO cells stably expressing hCB1R and treated with 0.1 nM—10 µM (A) cannabinoids; (B) cannabinoids + 100 nM ∆⁹-THC; (C) phytomolecules; and (D) phytomolecules + 100 nM ∆⁹-THC. Data were fit to a variable slope (four parameters) non-linear regression in GraphPad (v. 9). n ≥ 6 independent experiments were performed in duplicate. Data are expressed as mean ± SEM. K_i and E_min are reported in Table 1.