FIGURE 6.

In vivo effects of cannabinoids and select phytomolecules in male C57BL/6 mice. Male mice were treated with 10 mg/kg cannabinoids (A–C) or 10 mg/kg ∆⁹-THC + 10 mg/kg select phytomolecules i. p. (D–F) and assessed for catalepsy 5 min post-injection (A,D), body temperature 15 min post-injection (B,E), and nociception in the tail-flick assay 20 min post-injection (C,F). Data for catalepsy are represented as % MPE during a maximum 60 s trial. Data for the tail-flick assay are represented as % MPE during a maximum 20 s trial. All data were analyzed in GraphPad (v. 9). n = 5–10 animals per treatment group. Data are expressed as mean ± SEM. *p < 0.05, **p < 0.01, and ****p < 0.001 as determined by one-way ANOVA followed by Tukey’s post hoc test for multiple comparisons.