Table 11.

Scaffolds for delivery of IVT mRNA vaccines for infectious and cancerous diseases.

Vaccine Platform	Antigen	Delivery Platform	Preclinical/ Clinical Setting	Immune Response	Ref
IVT mRNA in SFliposomes	GFP	pHEMA scaffold	Mice	- Induction of local prolonged release of mRNA, high local transgene expression, and high transfection efficiency	[105]
IVT mRNA in SF liposomes	Ovalbumin	S-CS and O-Alg scaffold	Mice	- Slow release of mRNA from liposomes entrapped in scaffold - Increase local antigen expression, early production of ovalbumin-specific IgG, and increased IFN-γ producing cytotoxic T cells compared to protein vaccine or systemically delivered mRNA vaccine	[106]