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Representatives of DHA-based NDDSs and their functions. (A) Polymer-based NPs; (B) Tf-modified lipid-based NPs; (C) MOFs (inorganic-based NPs) designed for photodynamic therapy; (D) Magnetic NPs with Fe3+ served as a magnetic resonance imaging agent. DHA is released from the NDDSs once the drug vehicles are delivered to the tumor sites. The endoperoxide bridge of DHA is cleaved by Fe2+ to produce ROS and free radical intermediates for cancer therapy.
